Eriks Jankevics

TL;DR: It is shown that homozygous male mice with a targeted gene deletion of isoform 4 of the plasma membrane calcium/calmodulin-dependent calcium ATPase (PMCA), which is highly enriched in the sperm tail, are infertile due to severely impaired sperm motility, supporting the hypothesis of a pivotal role of the PMCA4 on the regulation of sperm function and intracellular Ca2+ levels.

TL;DR: Threshold levels of individual NFAT factors appear to be critical for apoptosis induction in effector T cells, and contrary to other NFATs, NFATc1/A is unable to promote apoptosis, suggesting that NFATd/A enhances effector functions without promoting apoptosis of effectors T cells.

TL;DR: The NF-AT transcription factors are characterized by a highly conserved DNA binding domain (is designated as Rel similarity domain) and a calcineurin binding domain this paper, and the binding of the Ca(2+)-dependent phosphatase calcINEurin to this region controls the nuclear import and exit of NF-ats.

TL;DR: Alternative polyadenylation events ensure the rapid accumulation of high concentrations of NF-ATc necessary to exceed critical threshold levels of NF -ATc for gene induction in effector T cells.

TL;DR: Observations indicate that irradiation-induced ETC up-regulate key components of germ-line cells, which potentially facilitate survival and propagation of the tumour cell population.