K
Karin Dillner
Researcher at Karolinska Institutet
Publications - 12
Citations - 683
Karin Dillner is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Prostate & Transgene. The author has an hindex of 10, co-authored 12 publications receiving 643 citations. Previous affiliations of Karin Dillner include University of Gothenburg.
Papers
More filters
Journal ArticleDOI
Development of pure prolactin receptor antagonists.
Sophie Bernichtein,Christine Kayser,Karin Dillner,Stéphanie Moulin,John J. Kopchick,Joseph A. Martial,Gunnar Norstedt,Olle Isaksson,Paul A. Kelly,Vincent Goffin +9 more
TL;DR: The development of new human PRL antagonists devoid of agonistic properties and therefore able to act as pure antagonists are described and are good candidates to be used as inhibitors of growth-promoting actions of PRL.
Journal ArticleDOI
Prostate Hyperplasia in a Transgenic Mouse with Prostate-Specific Expression of Prolactin
Jon Kindblom,Karin Dillner,Karin Dillner,Lena Sahlin,Fiona G. Robertson,Christopher J. Ormandy,Jan Törnell,Jan Törnell,Håkan Wennbo +8 more
TL;DR: The ability of PRL to promote, directly or indirectly, ductal morphogenesis in the developing prostate and further to induce abnormal growth primarily of the stroma in the adult gland in a setting of normal androgen levels is indicated.
Journal ArticleDOI
Gene Expression Profiling of Androgen Deficiency Predicts a Pathway of Prostate Apoptosis that Involves Genes Related to Oxidative Stress
See-Tong Pang,Karin Dillner,Karin Dillner,Xuxia Wu,Åke Pousette,Gunnar Norstedt,Amilcar Flores-Morales +6 more
TL;DR: It is hypothesized that modulation of redox status can be a factor of relevance in androgen withdrawal-induced prostate apoptosis and gene expression profiling provides a unique opportunity for understanding the molecular mechanisms of androgen actions in prostate gland.
Journal ArticleDOI
Prolactin (PRL) receptor gene expression in mouse adipose tissue: increases during lactation and in PRL-transgenic mice
Charlotte Ling,Gunnel Hellgren,Maria Gebre-Medhin,Karin Dillner,Håkan Wennbo,Björn Carlsson,Håkan Billig +6 more
TL;DR: A direct role for PRL, mediated by PRLR, in modulating physiological events in adipose tissue is suggested as well as up-regulates its own receptor in some tissues.
Journal ArticleDOI
Prostate development and carcinogenesis in prolactin receptor knockout mice.
Fiona G. Robertson,Jessica Harris,Matthew J. Naylor,Samantha R. Oakes,Jon Kindblom,Karin Dillner,Håkan Wennbo,Jan Törnell,Paul A. Kelly,Jeffrey E. Green,Christopher J. Ormandy +10 more
TL;DR: It is established that essential though subtle roles for prolactin in the regulation of prostate morphology, gene expression, SV40T-induced neoplasia, and reproductive function are established.