K
Karina Huynh
Researcher at Baker IDI Heart and Diabetes Institute
Publications - 40
Citations - 737
Karina Huynh is an academic researcher from Baker IDI Heart and Diabetes Institute. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 5, co-authored 6 publications receiving 628 citations.
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Journal ArticleDOI
Diabetic cardiomyopathy: Mechanisms and new treatment strategies targeting antioxidant signaling pathways
Karina Huynh,Bianca C. Bernardo,Julie R. McMullen,Julie R. McMullen,Rebecca H. Ritchie,Rebecca H. Ritchie +5 more
TL;DR: This work reviews the current evidence of molecular disturbances present in the diabetic heart, and their role in the development of diabetes-induced impairments in myocardial function and structure, and incorporates both the contribution of increased reactive oxygen species production and reduced antioxidant defenses to diabetic cardiomyopathy.
Journal ArticleDOI
Cardiac-Specific IGF-1 Receptor Transgenic Expression Protects Against Cardiac Fibrosis and Diastolic Dysfunction in a Mouse Model of Diabetic Cardiomyopathy
Karina Huynh,Julie R. McMullen,Tracey L Julius,Joon Win Tan,Jane E Love,Nelly Cemerlang,Helen Kiriazis,Xiao-Jun Du,Rebecca H. Ritchie,Rebecca H. Ritchie +9 more
TL;DR: In this paper, the authors examined whether cardiac-specific overexpression of IGF-1R prevents diabetes-induced myocardial remodeling and dysfunction associated with a murine model of diabetes.
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Targeting the upregulation of reactive oxygen species subsequent to hyperglycemia prevents type 1 diabetic cardiomyopathy in mice
Karina Huynh,Helen Kiriazis,Xiao-Jun Du,Jane E Love,Stephen P. Gray,Karin Jandeleit-Dahm,Julie R. McMullen,Julie R. McMullen,Julie R. McMullen,Rebecca H. Ritchie,Rebecca H. Ritchie +10 more
TL;DR: The hypothesis that targeting left-ventricular (LV) reactive oxygen species (ROS) upregulation subsequent to hyperglycemia attenuates type 1 diabetes-induced LV remodeling and dysfunction, accompanied by attenuated proinflammatory markers and cardiomyocyte apoptosis is tested.
Journal ArticleDOI
Insulin replacement limits progression of diabetic cardiomyopathy in the low-dose streptozotocin-induced diabetic rat:
Mitchel Tate,Minh Deo,Anh Cao,Anh Cao,Sally G Hood,Karina Huynh,Helen Kiriazis,Xiao Jun Du,Tracey L Julius,Gemma A. Figtree,Gregory J. Dusting,David M. Kaye,David M. Kaye,Rebecca H. Ritchie,Rebecca H. Ritchie +14 more
TL;DR: It is suggested that poor glucose control directly contributes towards the underlying features of experimental diabetic cardiomyopathy, at least in the early stages, and that adequate replacement ameliorates this.
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Chronic Administration of the Nitroxyl Donor 1-Nitrosocyclo Hexyl Acetate Limits Left Ventricular Diastolic Dysfunction in a Mouse Model of Diabetes Mellitus In Vivo
Nga Cao,Yung George Wong,Sarah Rosli,Helen Kiriazis,Karina Huynh,Chengxue Qin,Xiao-Jun Du,Barbara K Kemp-Harper,Rebecca H. Ritchie +8 more
TL;DR: These studies provide the first evidence that HNO donors may represent a promising strategy for treatment of diabetic cardiomyopathy and implies therapeutic efficacy in settings of chronic heart failure.