Karolline S. da Silva

TL;DR: The data reveal that A GEs impair glucose homeostasis in non-diabetic states of increased AGEs concentration; an effect that involves activation of endoplasmic reticulum- and inflammatory-stress and repression of Slc2a4/GLUT4 expression.

TL;DR: Aerobic exercise in vivo accelerates the traffic of cholesterol from macrophages to the liver contributing to prevention and regression of atherosclerosis, independently of changes in macrophage and aorta gene expression.

TL;DR: In the presence of CETP, AET positively influences gene expression in the arterial wall and macrophages of CETp-tg mice contributing to the RCT and prevention of atherosclerosis.

TL;DR: Because AGEs are highly consumed in modern diets and implicated in the progression of different kidney diseases, NAC could be a therapeutic intervention to decrease renal damage, considering that long-term restriction of dietary A GEs is difficult to achieve in practice.

TL;DR: AGE-albumin sensitizes adipose tissue to inflammation due to macrophage infiltration and reduces GLUT4, contributing to insulin resistance in healthy rats, and may be a useful tool in the prevention of AGE action on insulin resistance and long-term complications of DM.