K
Katarzyna Karwacz
Researcher at University College London
Publications - 18
Citations - 1994
Katarzyna Karwacz is an academic researcher from University College London. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 12, co-authored 18 publications receiving 1674 citations. Previous affiliations of Katarzyna Karwacz include Harvard University & Brigham and Women's Hospital.
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Journal ArticleDOI
Dynamic regulatory network controlling Th17 cell differentiation
Nir Yosef,Alex K. Shalek,Jellert T. Gaublomme,Hulin Jin,Youjin Lee,Amit Awasthi,Amit Awasthi,Chuan Wu,Katarzyna Karwacz,Sheng Xiao,Marsela Jorgolli,David Gennert,Rahul Satija,Arvind Shakya,Diana Lu,John J. Trombetta,Meenu R. Pillai,Peter J. Ratcliffe,Mathew L. Coleman,Mark Bix,Dean Tantin,Hongkun Park,Hongkun Park,Vijay K. Kuchroo,Vijay K. Kuchroo,Aviv Regev,Aviv Regev +26 more
TL;DR: This study identifies and validates 39 regulatory factors, embeds them within a comprehensive temporal network and reveals its organizational principles; it also highlights novel drug targets for controlling TH17 cell differentiation.
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CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity
Chao Wang,Nir Yosef,Nir Yosef,Jellert T. Gaublomme,Jellert T. Gaublomme,Chuan Wu,Youjin Lee,Clary B. Clish,James Kaminski,Sheng Xiao,Gerd Meyer zu Hörste,Mathias Pawlak,Yasuhiro Kishi,Yasuhiro Kishi,Nicole Joller,Katarzyna Karwacz,Chen Zhu,Maria Ordovas-Montanes,Asaf Madi,Asaf Madi,Ivo Wortman,Toru Miyazaki,Raymond A. Sobel,Hongkun Park,Hongkun Park,Aviv Regev,Aviv Regev,Vijay K. Kuchroo,Vijay K. Kuchroo +28 more
TL;DR: This study identifies CD5L as a critical regulator of the Th17 cell functional state and highlights the importance of lipid metabolism in balancing immune protection and disease induced by T cells.
Journal ArticleDOI
PD-L1 Co-Stimulation Contributes to Ligand-Induced T Cell Receptor Down-Modulation on \(CD8^+\) T Cells
Katarzyna Karwacz,Katarzyna Karwacz,Christopher Bricogne,Douglas C. MacDonald,Frederick Arce,Clare L. Bennett,Mary S. Collins,David Escors +7 more
TL;DR: Interference with PD‐L1/PD‐1 signalling markedly inhibits TCR down‐modulation leading to hyper‐activated, proliferative CD8 T cells as assessed in vitro and in vivo in an arthritis model.
CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity
Chao Wang,Nir Yosef,Nir Yosef,Jellert T. Gaublomme,Jellert T. Gaublomme,Chuan Wu,Youjin Lee,Clary B. Clish,James Kaminski,Sheng Xiao,Gerd Meyer zu Hörste,Mathias Pawlak,Yasuhiro Kishi,Yasuhiro Kishi,Nicole Joller,Katarzyna Karwacz,Chen Zhu,Maria Ordovas-Montanes,Asaf Madi,Asaf Madi,Ivo Wortman,Toru Miyazaki,Raymond A. Sobel,Hongkun Park,Hongkun Park,Aviv Regev,Aviv Regev,Vijay K. Kuchroo,Vijay K. Kuchroo +28 more
TL;DR: In this article, the authors used single-cell RNA-seq to identify CD5L/AIM as a regulator expressed in non-pathogenic, but not in pathogenic Th17 cells.
Journal ArticleDOI
HIV-1 Lentiviral vector immunogenicity is mediated by Toll-Like Receptor 3 (TLR3) and TLR7
Karine Breckpot,David Escors,Frederick Arce,Lucienne Lopes,Katarzyna Karwacz,Sandra Van Lint,Marleen Keyaerts,Mary Collins +7 more
TL;DR: Lentiviral activation of myeloid dendritic cells by lentiviral vectors is demonstrated, explaining their immunogenicity and allowing the rational development of strategies to manipulate the host's immune response to the transgene.