James Kaminski

TL;DR: The accessible chromatin landscape in exhausted CD8+ T cells is defined and shown that it is distinct from functional memory CD8 + T cells, suggesting that exhausted T cells are a distinct lineage.

TL;DR: This study identifies CD5L as a critical regulator of the Th17 cell functional state and highlights the importance of lipid metabolism in balancing immune protection and disease induced by T cells.

TL;DR: In this article, the authors used single-cell RNA-seq to identify CD5L/AIM as a regulator expressed in non-pathogenic, but not in pathogenic Th17 cells.

TL;DR: The developed ShortBRED (Short, Better Representative Extract Dataset) method is applied to profile antibiotic resistance protein families in the gut microbiomes of individuals from the United States, China, Malawi, and Venezuela, and supports antibiotic resistance as a core function in the human gut microbiome.

TL;DR: In this paper, a single-cell RNA sequencing and flux balance analysis was applied to associate metabolic states with T helper 17 (Th17) functional variability (pathogenic potential) and recovered a metabolic switch between glycolysis and fatty acid oxidation, akin to known Th17/regulatory T-cell differences, which were validated by metabolic assays.