K
Kate M. Fraser
Researcher at University of Otago
Publications - 11
Citations - 765
Kate M. Fraser is an academic researcher from University of Otago. The author has contributed to research in topics: Gene & Open reading frame. The author has an hindex of 9, co-authored 11 publications receiving 731 citations. Previous affiliations of Kate M. Fraser include Medical Research Council.
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Journal ArticleDOI
Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus.
TL;DR: A gene encoding a polypeptide with homology to mammalian vascular endothelial growth factors (VEGFs) has been discovered in the genome of orf virus (OV), a parapoxvirus that affects sheep and goats and, occasionally, humans.
Journal ArticleDOI
Comparative analysis of genome sequences of three isolates of Orf virus reveals unexpected sequence variation.
Andrew A. Mercer,Norihito Ueda,Sonja-Maria Friederichs,Kay Hofmann,Kate M. Fraser,Trudie Bateman,Stephen B. Fleming +6 more
TL;DR: The availability of genomic sequences of three orf virus isolates allowed us to more accurately assess likely coding regions and thereby revise published data for 24 genes and to predict two previously unrecognized genes.
Journal ArticleDOI
The structure and cloning of orf virus DNA
TL;DR: A map of cleavage sites for the restriction endonucleases EcoRI, HindIII, BamHI, HpaI, and KpnI for a New Zealand strain of orf virus (NZ2) DNA has been deduced.
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Conservation of gene structure and arrangement between vaccinia virus and orf virus.
TL;DR: The OV ORFs are arranged on the genome in an almost identical manner to their VAC counterparts revealing the common evolutionary origin of the two viruses despite the extreme difference in their G+C content.
Journal ArticleDOI
Conservation and variation in orf virus genomes.
TL;DR: The genomes of several orf virus strains were analyzed with the restriction endonucleases EcoRI, HindIII, BamHI, and KpnI, and cleavage site maps were deduced, and it was suggested that this internal variable region of NZ2 may provide sites for the insertion of foreign genes.