Katharina Gunkel

TL;DR: In vivo multiphoton laser-scanning microscopy of the entire brain metastatic cascade allowed unprecedented insights into how blood clot formation and von Willebrand factor deposition determine the arrest of circulating cancer cells and subsequent brain colonization in mice, discovering a novel and specific mechanism that is crucial for brain colonization.

TL;DR: The data identify temporary slow-cycling breast cancer cells as the dominant source of brain and other metastases and demonstrates that this can lead to better understanding of BMIC-relevant pathways, including potential new approaches to prevent BM in patients.

TL;DR: In this paper , the authors used Cox-regression to assess the influence of various factors on the probability of occurrence of dementia and MCI in IPS patients, including gender, age at DBS implantation, disease duration at the time of surgery, and motor impairment expressed as UPDRS III.