Journal ArticleDOI
Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures.
Katharina Zimmermann,Andreas Leffler,Alexandru Babes,Cruz Miguel Cendán,Richard W. Carr,Jin-ichi Kobayashi,Carla Nau,John N. Wood,Peter W. Reeh +8 more
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TLDR
This work shows that cooling excitable membranes progressively enhances the voltage-dependent slow inactivation of tetrodotoxin-sensitive VGSCs, and presents strong evidence for a specialized role of Nav1.8 in nociceptors as the critical molecule for the perception of cold pain and pain in the cold.Citations
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Cellular and Molecular Mechanisms of Pain
TL;DR: Genetic, electrophysiological, and pharmacological studies are elucidating the molecular mechanisms that underlie detection, coding, and modulation of noxious stimuli that generate pain.
Journal ArticleDOI
Nociceptors: the sensors of the pain pathway
TL;DR: Current work in this field is providing researchers with a more thorough understanding of nociceptor cell biology at molecular and systems levels and insight that will allow the targeted design of novel pain therapeutics.
Journal ArticleDOI
Nociceptors—Noxious Stimulus Detectors
Clifford J. Woolf,Qiufu Ma +1 more
TL;DR: The genesis of nociceptors during development and the intrinsic properties of nock-like neurons that enable them to transduce, conduct, and transmit nocICEptors are highlighted and how their phenotypic plasticity contributes to clinical pain is discussed.
Journal ArticleDOI
Nociceptor sensitization in pain pathogenesis
Michael S. Gold,G.F. Gebhart +1 more
TL;DR: This work focuses here on nociceptors: their excitability, their heterogeneity and their role in initiating and maintaining pain.
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Sodium Channels in Normal and Pathological Pain
TL;DR: The contribution of voltage-gated sodium channels to pain is reviewed, with Na(v)1.7 is of special interest because it has been linked to a spectrum of inherited human pain disorders and is upregulated along pain-signaling pathways after nervous system injuries.
References
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Journal ArticleDOI
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
TL;DR: These findings, together with the previous identification of the heat-sensitive channels VR1 and VRL-1, demonstrate that TRP channels detect temperatures over a wide range and are the principal sensors of thermal stimuli in the mammalian peripheral nervous system.
Journal ArticleDOI
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
Gina M. Story,Andrea M. Peier,Alison J. Reeve,Samer R. Eid,Johannes Mosbacher,Todd R. Hricik,Taryn J. Earley,Anne C. Hergarden,David Andersson,Sun Wook Hwang,Peter McIntyre,Timothy Jegla,Stuart Bevan,Ardem Patapoutian,Ardem Patapoutian +14 more
TL;DR: The characterization of ANKTM1 is described, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8, which is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM 8.
Journal ArticleDOI
International Union of Pharmacology. XLVIII. Nomenclature and Structure-Function Relationships of Voltage-Gated Calcium Channels
TL;DR: The molecular relationships and physiological functions of these calcium channel proteins are presented and comprehensive information on their molecular, genetic, physiological, and pharmacological properties is provided.
Journal ArticleDOI
A TRP Channel that Senses Cold Stimuli and Menthol
Andrea M. Peier,Aziz Moqrich,Anne C. Hergarden,Alison J. Reeve,David Andersson,Gina M. Story,Taryn J. Earley,Ilaria Dragoni,Peter McIntyre,Stuart Bevan,Ardem Patapoutian,Ardem Patapoutian +11 more
TL;DR: This work describes the cloning and characterization of TRPM8, a distant relative of VR1 that is specifically expressed in a subset of pain- and temperature-sensing neurons and implicates an expanded role for this family of ion channels in somatic sensory detection.
Journal ArticleDOI
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents.
Diana M. Bautista,Sven-Eric Jordt,Tetsuro Nikai,Pamela R. Tsuruda,Andrew J. Read,Jeannie Poblete,Ebenezer N. Yamoah,Allan I. Basbaum,David Julius +8 more
TL;DR: Using TRPA1-deficient mice, it is shown that this channel is the sole target through which mustard oil and garlic activate primary afferent nociceptors to produce inflammatory pain.
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An SCN9A channelopathy causes congenital inability to experience pain
James J. Cox,Frank Reimann,Adeline K Nicholas,Gemma K. Thornton,Emma Roberts,Kelly Springell,G. Karbani,Hussain Jafri,Jovaria Mannan,Yasmin Raashid,Lihadh Al-Gazali,Henan Hamamy,Enza Maria Valente,Shaun Gorman,Richard Aled Williams,Duncan McHale,John N. Wood,Fiona M. Gribble,C. Geoffrey Woods +18 more