Katherine A. Senese

TL;DR: In this article, the authors reviewed clinical features and treatment protocols of COVID-19 patients with immunosuppression after treatment with human convalescent plasma and discussed the time course and clinical features of recovery.

TL;DR: In this article, a meta-analytical approach was used to pool daily survival data from all controlled studies that reported Kaplan-Meier survival plots, and a directionally consistent pattern among studies arising from multiple levels of the epistemic hierarchy was found that convalescent plasma transfusion was generally associated with greater patient survival.

TL;DR: In this paper, the authors hypothesize that near-sourced convalescent plasma likely reflects the antigenic composition of local viral strains, and that convalescence plasma has a higher efficacy, as defined by death within 30 days of transfusion, when the convalecent plasma donor and treated patient were in close geographic proximity.

TL;DR: It is argued that during a global health emergency, the mosaic of evidence originating from multiple levels of the epistemic hierarchy should inform contemporary policy and healthcare decisions and convalescent plasma should be implemented at the immediate onset of future infectious disease outbreaks.

TL;DR: In this article , the authors evaluated the coagulation profile of COVID-19 convalescent plasma and found that pathogen reduction increased activated partial thromboplastin time and thrombin time.