K
Katherine Dawson
Researcher at Biogen Idec
Publications - 59
Citations - 4254
Katherine Dawson is an academic researcher from Biogen Idec. The author has contributed to research in topics: Dimethyl fumarate & Multiple sclerosis. The author has an hindex of 20, co-authored 59 publications receiving 3846 citations.
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Journal ArticleDOI
Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis
Ralf Gold,Ludwig Kappos,Douglas L. Arnold,Amit Bar-Or,Gavin Giovannoni,Krzysztof Selmaj,Carlo Tornatore,Marianne T. Sweetser,Minhua Yang,Sarah Sheikh,Katherine Dawson,Define Study Investigators +11 more
TL;DR: In patients with relapsing-remitting multiple sclerosis, both BG-12 regimens, as compared with placebo, significantly reduced the proportion of patients who had a relapse, the annualized relapse rate, the rate of disability progression, and the number of lesions on MRI.
Journal ArticleDOI
Placebo-Controlled Phase 3 Study of Oral BG-12 or Glatiramer in Multiple Sclerosis
Robert J. Fox,David Miller,J. Theodore Phillips,Michael Hutchinson,Eva Havrdova,Mariko Kita,Minhua Yang,Kartik Raghupathi,Mark Novas,Marianne T. Sweetser,Vissia Viglietta,Katherine Dawson,Christian Sindic +12 more
TL;DR: In patients with relapsing-remitting multiple sclerosis, BG-12 (at both doses) and glatiramer acetate significantly reduced relapse rates and improved neuroradiologic outcomes relative to placebo.
Journal ArticleDOI
Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study
Ludwig Kappos,Ralf Gold,David Miller,David G. MacManus,Eva Havrdova,Volker Limmroth,Chris H. Polman,Klaus Schmierer,Tarek A. Yousry,Minhua Yang,Mefkure Eraksoy,Eva Meluzínová,Ivan Rektor,Katherine Dawson,Alfred Sandrock,Gilmore O'neill +15 more
TL;DR: The anti-inflammatory effects and favourable safety profile of BG00012 warrant further long-term phase III studies in large patient groups.
Journal ArticleDOI
BG-12 (dimethyl fumarate): a review of mechanism of action, efficacy, and safety
Robert J. Fox,Mariko Kita,Stanley Cohan,Lily Jung Henson,Javier Zambrano,Robert H. Scannevin,John O'Gorman,Mark Novas,Katherine Dawson,J. Theodore Phillips +9 more
TL;DR: BG-12 may have cytoprotective and anti-inflammatory properties that contribute to its efficacy among patients with RRMS, and findings from phase 2 and 3 studies further support BG-12 as an effective initial therapy.
Journal ArticleDOI
Manufacturer's Response to Case Reports of PML
TL;DR: Ermis et al. as mentioned in this paper reported progressive multifocal leukoencephalopathy (PML) in two patients with psoriasis who were being treated with Fumaderm (Biogen Idec) or a compounded version of fumaric acid esters (FAEs) referred to as Psorinovo (compounding pharmacy, Mierlo-Hout).