K
Klaus Schmierer
Researcher at Queen Mary University of London
Publications - 195
Citations - 8104
Klaus Schmierer is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Multiple sclerosis & Medicine. The author has an hindex of 40, co-authored 169 publications receiving 6739 citations. Previous affiliations of Klaus Schmierer include Royal London Hospital & Humboldt University of Berlin.
Papers
More filters
Journal ArticleDOI
Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain
Klaus Schmierer,Francesco Scaravilli,Daniel R. Altmann,Daniel R. Altmann,Gareth J. Barker,Gareth J. Barker,David Miller +6 more
TL;DR: MTR is affected by myelin content in MS white matter, and the extent of gliosis was detected using morphometric and digital imaging techniques.
Journal ArticleDOI
Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study
Ludwig Kappos,Ralf Gold,David Miller,David G. MacManus,Eva Havrdova,Volker Limmroth,Chris H. Polman,Klaus Schmierer,Tarek A. Yousry,Minhua Yang,Mefkure Eraksoy,Eva Meluzínová,Ivan Rektor,Katherine Dawson,Alfred Sandrock,Gilmore O'neill +15 more
TL;DR: The anti-inflammatory effects and favourable safety profile of BG00012 warrant further long-term phase III studies in large patient groups.
Journal ArticleDOI
Diffusion tensor imaging of post mortem multiple sclerosis brain
Klaus Schmierer,Claudia A. M. Wheeler-Kingshott,P A Boulby,Francesco Scaravilli,Daniel R. Altmann,Gareth J. Barker,Paul S. Tofts,David Miller +7 more
TL;DR: It is suggested that FA and MD are affected by myelin content and – to a lesser degree – axonal count in post mortem MS brain.
Journal ArticleDOI
No Cerebrocervical Venous Congestion in Patients with Multiple Sclerosis
Florian Doepp,Friedemann Paul,José M. Valdueza,Klaus Schmierer,Klaus Schmierer,Stephan J. Schreiber +5 more
TL;DR: Multiple sclerosis (MS) is characterized by demyelination centered around cerebral veins, and recent studies suggested this topographic pattern may be caused by venous congestion, a condition termed chronic cerebrospinal venous insufficiency (CCSVI).
Journal ArticleDOI
Quantitative magnetic resonance of postmortem multiple sclerosis brain before and after fixation.
Klaus Schmierer,Claudia A. M. Wheeler-Kingshott,Daniel J. Tozer,Phil A. Boulby,Harold G. Parkes,Tarek A. Yousry,Francesco Scaravilli,Gareth J. Barker,Paul S. Tofts,David Miller +9 more
TL;DR: Unfixed and fixed postmortem multiple sclerosis (MS) brain is being used to probe pathology underlying quantitative MR (qMR) changes, and diffusivity measures were lower in unfixed MS brain, and dropped further following fixation (except for FA).