Kathie-Anne Walters

TL;DR: A DNA sequence database that includes a 500–base pair region of the HBV polymerase gene from 20 patients with clinical manifestations of lamivudine resistance is reported, revealing two patterns of amino acid substitutions in the tyrosine, methionine, as partate, aspartate (YMDD) nucleotide‐binding locus of theHBV polymerases.

TL;DR: This work has identified a previously unknown IAV protein that modulates the host response to infection, a finding with important implications for understanding IAV pathogenesis.

TL;DR: In this paper, the authors performed proteomic and lipidomic profiling over a time course of acute hepatitis C virus (HCV) infection in cultured Huh-7.5 cells to gain new insights into the intracellular processes influenced by this virus.

TL;DR: The data support a novel model that links a mixed EM signature with stemness in individual cells, luminal and basal cell lines, in vivo xenograft mouse models, and in all breast cancer subtypes and suggest that targeting E/M heterogeneity by eliminating hybrid E-M cells and cooperation between E and M cell-types could improve breast cancer patient survival independent of breast cancer-subtype.

TL;DR: The utility of the approach to obtain new insights into post-transcriptional gene regulation at the miRNA level in complex human diseases is demonstrated as the framework for future experimental analyses is provided.