Sharon Lederer

TL;DR: Comparing acute pathogenic SIV infection in pigtailed macaques to non-pathogenic infection in African green monkeys indicates that loss of the Th17 to Treg balance is related to SIV disease progression.

TL;DR: The utility of the approach to obtain new insights into post-transcriptional gene regulation at the miRNA level in complex human diseases is demonstrated as the framework for future experimental analyses is provided.

TL;DR: In this paper, gene expression changes that were unique to either model were detected in the lymph nodes at the time of peak viral load, with a shift toward cellular stress pathways and Th1 profiles during pathogenic infection, with strong and sustained type I and II interferon responses.

TL;DR: Gene ontology analysis and data suggest that HCV mediates direct cytopathic effects through deregulation of the cell cycle and that this process may contribute to liver disease progression.

TL;DR: The 1918 NS1 gene may have contributed to the virulence of the 1918 pandemic virus by disrupting the innate immune response, inducing hypercytokinemia, and by blocking the transcription of certain lipid-based proinflammatory mediators that function as part of the host antiviral response.