K
Kathleen A. Burke
Researcher at Brown University
Publications - 5
Citations - 1715
Kathleen A. Burke is an academic researcher from Brown University. The author has contributed to research in topics: Protein aggregation & C-terminus. The author has an hindex of 5, co-authored 5 publications receiving 1228 citations.
Papers
More filters
Journal ArticleDOI
Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II
TL;DR: It is proposed that disordered protein granules, even those made of aggregation-prone prion-like domains, are dynamic and disordered molecular assemblies with transiently formed protein-protein contacts.
Journal ArticleDOI
Phosphorylation of the FUS low‐complexity domain disrupts phase separation, aggregation, and toxicity
Zachary T. Monahan,Veronica H Ryan,Abigail M. Janke,Kathleen A. Burke,Shannon N Rhoads,Gül H. Zerze,Robert N. O'Meally,Gregory L. Dignon,Alexander E. Conicella,Wenwei Zheng,Robert B. Best,Robert N. Cole,Jeetain Mittal,Frank Shewmaker,Nicolas L. Fawzi +14 more
TL;DR: It is shown that phosphomimetic FUS reduces aggregation in human and yeast cell models, and can ameliorate FUS‐associated cytotoxicity, suggesting a potential treatment pathway amenable to pharmacologic modulation.
Journal ArticleDOI
Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation.
Veronica H Ryan,Gregory L. Dignon,Gül H. Zerze,C.V. Chabata,Rute Silva,Alexander E. Conicella,Joshua Amaya,Kathleen A. Burke,Jeetain Mittal,Nicolas L. Fawzi +9 more
TL;DR: A unified structural view of hnRNPA2 self-assembly, aggregation, and interaction and the distinct effects of small chemical changes-disease mutations and arginine methylation-on these assemblies are provided.
Journal ArticleDOI
Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites
Takuya Yoshizawa,Rustam Ali,Jenny Jiou,Ho Yee Joyce Fung,Kathleen A. Burke,Seung Joong Kim,Yuan Lin,Yuan Lin,William B. Peeples,William B. Peeples,Daniel J. Saltzberg,Michael M. Soniat,Jordan M. Baumhardt,Rudolf Oldenbourg,Andrej Sali,Nicolas L. Fawzi,Michael K. Rosen,Michael K. Rosen,Yuh Min Chook,Yuh Min Chook +19 more
TL;DR: A model where high-affinity binding of karyopherin-β2 to the FUS PY-NLS tethers the proteins together, allowing multiple, distributed weak intermolecular contacts to disrupt FUS self-association, blocking LLPS is proposed.
Journal ArticleDOI
Lysines in the RNA Polymerase II C-Terminal Domain Contribute to TAF15 Fibril Recruitment
Abigail M. Janke,Da Hee Seo,Vahid Rahmanian,Alexander E. Conicella,Kaylee L. Mathews,Kathleen A. Burke,Jeetain Mittal,Nicolas L. Fawzi +7 more
TL;DR: Weak, multivalent interactions between TAF15 fibrils and heptads throughout RNA pol II CTD collectively mediate complex formation.