T
Takuya Yoshizawa
Researcher at Ritsumeikan University
Publications - 33
Citations - 657
Takuya Yoshizawa is an academic researcher from Ritsumeikan University. The author has contributed to research in topics: Chemistry & FtsZ. The author has an hindex of 7, co-authored 28 publications receiving 388 citations. Previous affiliations of Takuya Yoshizawa include University of Texas Southwestern Medical Center & Yokohama City University.
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Journal ArticleDOI
Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites
Takuya Yoshizawa,Rustam Ali,Jenny Jiou,Ho Yee Joyce Fung,Kathleen A. Burke,Seung Joong Kim,Yuan Lin,Yuan Lin,William B. Peeples,William B. Peeples,Daniel J. Saltzberg,Michael M. Soniat,Jordan M. Baumhardt,Rudolf Oldenbourg,Andrej Sali,Nicolas L. Fawzi,Michael K. Rosen,Michael K. Rosen,Yuh Min Chook,Yuh Min Chook +19 more
TL;DR: A model where high-affinity binding of karyopherin-β2 to the FUS PY-NLS tethers the proteins together, allowing multiple, distributed weak intermolecular contacts to disrupt FUS self-association, blocking LLPS is proposed.
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Biological phase separation: cell biology meets biophysics
TL;DR: In this review, recent discoveries related to biological phase separation including stress granule formation, chromatin regulation, and processes in the origin and evolution of life are evaluated.
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Structural basis for inhibition of xyloglucan-specific endo-β-1,4-glucanase (XEG) by XEG-protein inhibitor.
TL;DR: The findings imply that plants have evolved structures of GHIPs to inhibit different GH family members that attack their cell walls, which is a great threat to many plants.
Journal ArticleDOI
Crystal structure of basic 7S globulin, a xyloglucan‐specific endo‐β‐1,4‐glucanase inhibitor protein‐like protein from soybean lacking inhibitory activity against endo‐β‐glucanase
Takuya Yoshizawa,Toshiyuki Shimizu,Mayuki Yamabe,Misako Taichi,Yuji Nishiuchi,Naoki Shichijo,Satoru Unzai,Hisashi Hirano,Mamoru Sato,Hiroshi Hashimoto +9 more
TL;DR: The crystal structure of basic 7S globulin (Bg7S), a XEGIP from soybean, is determined, which represents the first three‐dimensional structure ofXEGIP, and will provide significant clues for understanding the physiological role of Bg6S.
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Hybrid Rubisco with Complete Replacement of Rice Rubisco Small Subunits by Sorghum Counterparts Confers C4 Plant-like High Catalytic Activity.
Hiroyoshi Matsumura,Keita Shiomi,Akito Yamamoto,Yuri Taketani,Noriyuki Kobayashi,Takuya Yoshizawa,Shun-ichi Tanaka,Hiroki Yoshikawa,Masaki Endo,Hiroshi Fukayama +9 more
TL;DR: High-resolution crystal structural analysis of the wild-type Rubisco and hybrid-Rubisco revealed the structural differences around the central pore ofRubisco and the βC-βD hairpin in RbcS, and it is speculated that such differences may impact the flexibility of Rubisco catalytic site and change the catalytic properties.