N
Nicolas L. Fawzi
Researcher at Brown University
Publications - 86
Citations - 8067
Nicolas L. Fawzi is an academic researcher from Brown University. The author has contributed to research in topics: Chemistry & Biology. The author has an hindex of 32, co-authored 76 publications receiving 5368 citations. Previous affiliations of Nicolas L. Fawzi include University of California, Berkeley & National Institutes of Health.
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Journal ArticleDOI
Protein Phase Separation: A New Phase in Cell Biology.
Steven Boeynaems,Steven Boeynaems,Simon Alberti,Nicolas L. Fawzi,Tanja Mittag,Magdalini Polymenidou,Frederic Rousseau,Frederic Rousseau,Joost Schymkowitz,Joost Schymkowitz,James Shorter,Benjamin Wolozin,Ludo Van Den Bosch,Peter Tompa,Peter Tompa,Monika Fuxreiter +15 more
TL;DR: A combination of techniques from cell biology, biophysics, physical chemistry, structural biology, and bioinformatics are starting to help establish the molecular principles of an emerging field, thus paving the way for exciting discoveries, including novel therapeutic approaches for the treatment of age-related disorders.
Journal ArticleDOI
Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II
TL;DR: It is proposed that disordered protein granules, even those made of aggregation-prone prion-like domains, are dynamic and disordered molecular assemblies with transiently formed protein-protein contacts.
Journal ArticleDOI
ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain.
TL;DR: Atomic details on the structure and assembly of the low-complexity CTD of TDP-43 into liquid-liquid phase-separated in vitro granules are provided and it is demonstrated that ALS-associated variants disrupt interactions within granules.
Journal ArticleDOI
Phosphorylation of the FUS low‐complexity domain disrupts phase separation, aggregation, and toxicity
Zachary T. Monahan,Veronica H Ryan,Abigail M. Janke,Kathleen A. Burke,Shannon N Rhoads,Gül H. Zerze,Robert N. O'Meally,Gregory L. Dignon,Alexander E. Conicella,Wenwei Zheng,Robert B. Best,Robert N. Cole,Jeetain Mittal,Frank Shewmaker,Nicolas L. Fawzi +14 more
TL;DR: It is shown that phosphomimetic FUS reduces aggregation in human and yeast cell models, and can ameliorate FUS‐associated cytotoxicity, suggesting a potential treatment pathway amenable to pharmacologic modulation.
Journal ArticleDOI
Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics
Steven Boeynaems,Elke Bogaert,Denes Kovacs,Albert Konijnenberg,Evy Timmerman,Alex Volkov,Mainak Guharoy,Mathias De Decker,Tom Jaspers,Veronica H Ryan,Abigail M. Janke,Pieter Baatsen,Thomas Vercruysse,Regina-Maria Kolaitis,Dirk Daelemans,J. Paul Taylor,Nancy Kedersha,Paul A. Anderson,Francis Impens,Frank Sobott,Frank Sobott,Joost Schymkowitz,Joost Schymkowitz,Frederic Rousseau,Frederic Rousseau,Nicolas L. Fawzi,Wim Robberecht,Philip Van Damme,Peter Tompa,Peter Tompa,Ludo Van Den Bosch +30 more
TL;DR: In this article, the authors identify an active role for arginine-rich domains in phase separations of ALS-linked stress granule proteins, and demonstrate that DPRs affect nucleocytoplasmic transport, leading to an important role for DPRs in the pathogenesis of C9orf72 ALS/FTLD.