K
Kathleen A. McDonough
Researcher at New York State Department of Health
Publications - 60
Citations - 2768
Kathleen A. McDonough is an academic researcher from New York State Department of Health. The author has contributed to research in topics: Gene & Mycobacterium tuberculosis. The author has an hindex of 24, co-authored 51 publications receiving 2347 citations. Previous affiliations of Kathleen A. McDonough include Oklahoma State Department of Health & State University of New York System.
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Journal ArticleDOI
Genome Sequence of Yersinia pestis KIM
Wen Deng,Valerie Burland,Guy Plunkett,Adam T. Boutin,George F. Mayhew,Paul Liss,Nicole T. Perna,Debra J. Rose,Bob Mau,Shiguo Zhou,David C. Schwartz,Jaqueline D. Fetherston,Luther E. Lindler,Robert R. Brubaker,Gregory V. Plano,Susan C. Straley,Kathleen A. McDonough,Matthew L. Nilles,Jyl S. Matson,Frederick R. Blattner,Robert D. Perry +20 more
TL;DR: The KIM genome sequence was compared with that of Y. pestis CO92, biovar Orientalis, revealing homologous sequences but a remarkable amount of genome rearrangement for strains so closely related, in a manner consistent with present knowledge of replication and recombination.
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The myriad roles of cyclic AMP in microbial pathogens: from signal to sword
TL;DR: The many roles of cAMP are discussed, which include the coordination of intracellular processes, such as virulence gene expression, with extracellular signals from the environment, and the manipulation of host immunity by increasing cAMP levels in host cells during infection.
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Functional classification of cNMP-binding proteins and nucleotide cyclases with implications for novel regulatory pathways in Mycobacterium tuberculosis.
TL;DR: Analysis of cyclic nucleotide (cNMP)-binding protein and nucleotide cyclase superfamilies using Bayesian computational methods of protein family identification and classification revealed subtle differences in sequence conservation of the active site that distinguish the five classes of cyclases.
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Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a Cyclic AMP Receptor Protein-Like DNA Binding Protein
TL;DR: The first direct evidence for cAMP binding to a transcription factor in Mycobacterium tuberculosis is provided, suggesting a role for camp signal transduction in M. tuberculosis and implicating CRP(Mt) as a cAMP-responsive global regulator.
Journal ArticleDOI
Multiple small RNAs identified in Mycobacterium bovis BCG are also expressed in Mycobacterium tuberculosis and Mycobacterium smegmatis
Jeanne M. DiChiara,Lydia M. Contreras-Martinez,Jonathan Livny,Dorie Smith,Kathleen A. McDonough,Marlene Belfort +5 more
TL;DR: 34 novel small RNAs (sRNAs) are found in the TB-complex M. bovis BCG, using a combination of experimental and computational approaches, and various features and regulatory aspects of some of these sRNAs are discussed.