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Mark J. Cameron
Researcher at Case Western Reserve University
Publications - 141
Citations - 8457
Mark J. Cameron is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: T cell & Immune system. The author has an hindex of 41, co-authored 127 publications receiving 6886 citations. Previous affiliations of Mark J. Cameron include University of Western Ontario & Toronto General Hospital.
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Journal ArticleDOI
SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.
Yixuan J. Hou,Kenichi Okuda,Caitlin E. Edwards,David R. Martinez,Takanori Asakura,Kenneth H. Dinnon,Takafumi Kato,Rhianna E. Lee,Boyd Yount,Teresa M. Mascenik,Gang Chen,Kenneth N. Olivier,Andrew J. Ghio,Longping V. Tse,Sarah R. Leist,Lisa E. Gralinski,Alexandra Schäfer,Hong Dang,Rodney C. Gilmore,Satoko Nakano,Ling Sun,M. Leslie Fulcher,Alessandra Livraghi-Butrico,Nathan I. Nicely,Mark J. Cameron,Cheryl M. Cameron,David J. Kelvin,David J. Kelvin,Aravinda M. de Silva,David M. Margolis,Alena J. Markmann,Luther A. Bartelt,Ross E. Zumwalt,Fernando J. Martinez,Steven P. Salvatore,Alain C. Borczuk,Purushothama Rao Tata,Vishwaraj Sontake,Adam J. Kimple,Ilona Jaspers,Wanda K. O'Neal,Scott H. Randell,Richard C. Boucher,Ralph S. Baric +43 more
TL;DR: The nasal susceptibility to SARS-CoV-2 with likely subsequent aspiration-mediated virus seeding to the lung in SARS/COVID-19 pathogenesis is highlighted and reagents provide a foundation for investigations into virus-host interactions in protective immunity, host susceptibility, and virus pathogenesis.
Journal ArticleDOI
Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses
Denis Gaucher,René Therrien,Nadia Kettaf,Bastian R. Angermann,Geneviève Boucher,Abdelali Filali-Mouhim,Janice M. Moser,Riyaz Mehta,Donald Drake,Erika Castro,Rama Akondy,Aline Rinfret,Bader Yassine-Diab,Elias A. Said,Younes Chouikh,Mark J. Cameron,Robert Clum,David J. Kelvin,Roland Somogyi,Larry D. Greller,Robert S. Balderas,Peter Wilkinson,Giuseppe Pantaleo,Jim Tartaglia,Elias K. Haddad,Rafick Pierre Sekaly +25 more
TL;DR: The results clearly show that the immune response to a strong vaccine is preceded by coordinated induction of master transcription factors that lead to the development of a broad, polyfunctional, and persistent immune response that integrates all effector cells of the immune system.
Journal ArticleDOI
Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy.
Julian Elliott,Fiona Wightman,Ajantha Solomon,Khader Ghneim,Jeffrey D. Ahlers,Mark J. Cameron,Miranda Zoe Denham Smith,Tim Spelman,James H McMahon,Pushparaj Velayudham,Gregor J. Brown,Janine Roney,Jo Watson,Miles Prince,Jennifer F Hoy,Nicolas Chomont,Rémi Fromentin,Francesco A. Procopio,Joumana Zeidan,Sarah Palmer,Lina Odevall,Ricky W. Johnstone,Ben P. Martin,Elizabeth Sinclair,Steven G. Deeks,Daria J. Hazuda,Paul U. Cameron,Rafick-Pierre Sekaly,Sharon R Lewin +28 more
TL;DR: Vorinostat induced a significant and sustained increase in HIV transcription from latency in the majority of HIV-infected patients, however, additional interventions will be needed to efficiently induce virus production and ultimately eliminate latently infected cells.
Journal ArticleDOI
Interferon-Mediated Immunopathological Events Are Associated with Atypical Innate and Adaptive Immune Responses in Patients with Severe Acute Respiratory Syndrome
Mark J. Cameron,Longsi Ran,Luoling Xu,Ali Danesh,Jesus F. Bermejo-Martin,Cheryl M. Cameron,Matthew P. Muller,Wayne L. Gold,Wayne L. Gold,Susan E. Richardson,Susan M. Poutanen,Susan M. Poutanen,Barbara M. Willey,Mark E. DeVries,Yuan Fang,Charit Seneviratne,Steven E. Bosinger,Desmond Persad,Peter Wilkinson,Larry D. Greller,Roland Somogyi,Atul Humar,Atul Humar,Shaf Keshavjee,Marie Louie,Mark Loeb,James Brunton,Allison McGeer,David J. Kelvin,David J. Kelvin,David J. Kelvin +30 more
TL;DR: It is argued that unregulated IFN responses during acute-phase SARS may culminate in a malfunction of the switch from innate immunity to adaptive immunity, and the potential for the use of the gene signatures described in this study to better assess the immunopathology and clinical management of severe viral infections.
Journal ArticleDOI
Human immunopathogenesis of severe acute respiratory syndrome (SARS)
Mark J. Cameron,Jesus F. Bermejo-Martin,Ali Danesh,Ali Danesh,Matthew P. Muller,Matthew P. Muller,David J. Kelvin,David J. Kelvin +7 more
TL;DR: It is contended that dysregulated type I and II interferon responses during SARS may culminate in a failure of the switch from hyper-innate immunity to protective adaptive immune responses in the human host.