K
Katrin Ehrhardt
Researcher at University of Freiburg
Publications - 7
Citations - 157
Katrin Ehrhardt is an academic researcher from University of Freiburg. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 3 publications receiving 126 citations.
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Journal ArticleDOI
Human cytomegalovirus Fcγ binding proteins gp34 and gp68 antagonize Fcγ receptors I, II and III.
Eugenia Corrales-Aguilar,Mirko Trilling,Katja Hunold,Manuela Fiedler,Vu Thuy Khanh Le,Henrike Reinhard,Katrin Ehrhardt,Eva Mercé-Maldonado,Enver Aliyev,Albert Zimmermann,David C. Johnson,Hartmut Hengel +11 more
TL;DR: Surface immune-precipitation showed that both HCMV-encoded Fcγ binding proteins have the capacity to bind trastuzumab antibody-HER2 antigen complexes demonstrating simultaneous linkage of immune IgG with antigen and the H CMV inhibitors on the plasma membrane.
Journal ArticleDOI
Hierarchical and Redundant Roles of Activating FcγRs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies.
Silvie Van den Hoecke,Katrin Ehrhardt,Annasaheb Kolpe,Karim El Bakkouri,Lei Deng,Hendrik Grootaert,Steve Schoonooghe,Anouk Smet,Mostafa Bentahir,Kenny Roose,Michael Schotsaert,Bert Schepens,Nico Callewaert,Falk Nimmerjahn,Peter Staeheli,Hartmut Hengel,Xavier Saelens +16 more
TL;DR: It is shown here that two M2e-specific monoclonal antibodies with close to identical antigen-binding specificities and affinities have a very different in vivo protective potential that is controlled by their capacity to interact with activating Fcγ receptors.
Journal ArticleDOI
Immunoactivation induced by chronic viral infection inhibits viral replication and drives immunosuppression through sustained IFN-I responses
Nadine Honke,Nadine Honke,Namir Shaabani,Namir Shaabani,Katja Merches,A Gassa,Anke R. M. Kraft,Katrin Ehrhardt,Dieter Häussinger,Max Löhning,Ulf Dittmer,Hartmut Hengel,Mike Recher,Philipp A. Lang,Karl S. Lang,Karl S. Lang +15 more
TL;DR: It is found that chronic infection leads to sustained IFN‐I action, which is responsible for the absence of an antiviral immune response against a secondary viral infection.
Journal ArticleDOI
Cross-Talk Between the Intestinal Epithelium and Salmonella Typhimurium
Sandrine Ménard,Sonia Lacroix-Lamandé,Katrin Ehrhardt,Jin Yan,Guntram A. Grassl,Agnès Wiedemann +5 more
TL;DR: The purpose of this review is to summarize the current knowledge on the molecular dialogue between STm and the various cell types constituting the intestinal epithelium with a focus on the mechanisms developed by STm to cross the intestines and access to subepithelial or systemic sites and survive host defense mechanisms.
Journal ArticleDOI
Pathometagenomics reveals susceptibility to intestinal infection by Morganella to be mediated by the blood group-related B4galnt2 gene in wild mice
Marie-Jose Vallier,Abdulhadi Suwandi,Katrin Ehrhardt,Meriem Belheouane,David Berry,Aleksa Cepic,Alibek Galeev,Jill M. Johnsen,Guntram A. Grassl,John F. Baines +9 more
TL;DR: In this paper , the authors employed a pathometagenomic approach in a wild mouse population, which combines bacterial 16S rRNA gene-based community profiling with histopathology of gut tissue, to identify candidate pathogens for which resistance could be mediated by B4galnt2 genotype.