K
Katrin Tschöp
Researcher at Harvard University
Publications - 16
Citations - 877
Katrin Tschöp is an academic researcher from Harvard University. The author has contributed to research in topics: Cyclin-dependent kinase & Cyclin A. The author has an hindex of 12, co-authored 16 publications receiving 811 citations. Previous affiliations of Katrin Tschöp include Leipzig University.
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Journal ArticleDOI
Pumilio facilitates miRNA regulation of the E2F3 oncogene
TL;DR: It is suggested that Pumilio-miRNA repression of E2F3 translation provides an important level of E 2F regulation that is frequently abrogated in cancer cells.
Journal ArticleDOI
Conserved Antagonism between JMJD2A/KDM4A and HP1γ during Cell Cycle Progression
Joshua C. Black,Andrew E. Allen,Capucine Van Rechem,Emily Forbes,Michelle S. Longworth,Katrin Tschöp,Claire A. Rinehart,Jonathan Quiton,Ryan M. Walsh,Andrea Smallwood,Nicholas J. Dyson,Johnathan R. Whetstine +11 more
TL;DR: A conserved and unappreciated role for the JMJD2A/KDM4A H3K9/36 tridemethylase in cell cycle progression is identified and a highly conserved model whereby JM JD2A regulates DNA replication by antagonizing HP1γ and controlling chromatin accessibility is described.
Journal ArticleDOI
A kinase shRNA screen links LATS2 and the pRB tumor suppressor.
Katrin Tschöp,Andrew R. Conery,Larisa Litovchick,James A. DeCaprio,Jeffrey Settleman,Ed Harlow,Nicholas J. Dyson +6 more
TL;DR: A functional connection between the pRB and Hippo tumor suppressor pathways is revealed, and it is suggested that low levels of LATS2 may undermine the ability of pRB to induce a permanent cell cycle arrest in tumor cells.
Journal ArticleDOI
Loss of RBF1 changes glutamine catabolism
Brandon Nicolay,Paulo A. Gameiro,Paulo A. Gameiro,Paulo A. Gameiro,Katrin Tschöp,Michael Korenjak,Andreas M. Heilmann,John M. Asara,Gregory Stephanopoulos,Othon Iliopoulos,Nicholas J. Dyson +10 more
TL;DR: The results show that the inactivation of RB proteins causes metabolic reprogramming and that these consequences of RBF/RB function are present in both flies and human cell lines.
Journal ArticleDOI
Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation
Brandon Nicolay,Paul S. Danielian,Filippos Kottakis,John D. Lapek,Ioannis Sanidas,Wayne O. Miles,Mantre Dehnad,Mantre Dehnad,Katrin Tschöp,Jessica J. Gierut,Amity L. Manning,Robert Morris,Kevin M. Haigis,Nabeel Bardeesy,Jacqueline A. Lees,Wilhelm Haas,Nicholas J. Dyson +16 more
TL;DR: Proteomic analyses provide a new perspective on Rb/RB1 mutation, highlighting the importance of pRb for mitochondrial function and suggesting vulnerabilities for treatment.