L
Larisa Litovchick
Researcher at Virginia Commonwealth University
Publications - 39
Citations - 2121
Larisa Litovchick is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: DREAM complex & E2F. The author has an hindex of 19, co-authored 37 publications receiving 1782 citations. Previous affiliations of Larisa Litovchick include Harvard University & Brigham and Women's Hospital.
Papers
More filters
Journal ArticleDOI
Evolutionarily Conserved Multisubunit RBL2/p130 and E2F4 Protein Complex Represses Human Cell Cycle-Dependent Genes in Quiescence
Larisa Litovchick,Subhashini Sadasivam,Laurence Florens,Xiaopeng Zhu,Selene K. Swanson,Soundarapandian Velmurugan,Runsheng Chen,Michael P. Washburn,X. Shirley Liu,James A. DeCaprio +9 more
TL;DR: An evolutionarily conserved multisubunit protein complex that contains p130 and E2F4, but not pRB, and mediates the repression of cell cycle-dependent genes in quiescence is revealed.
Journal ArticleDOI
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins
Orit Rozenblatt-Rosen,Rahul C. Deo,Rahul C. Deo,Megha Padi,Guillaume Adelmant,Michael A. Calderwood,Thomas Rolland,Miranda Grace,Miranda Grace,Amélie Dricot,Manor Askenazi,Maria Tavares,Sam Pevzner,Sam Pevzner,Fieda Abderazzaq,Danielle Byrdsong,Anne-Ruxandra Carvunis,Alyce A. Chen,Alyce A. Chen,Jingwei Cheng,Jingwei Cheng,Mick Correll,Melissa Duarte,Melissa Duarte,Changyu Fan,Mariet C.W. Feltkamp,Scott B. Ficarro,Rachel Franchi,Rachel Franchi,Brijesh K. Garg,Natali Gulbahce,Tong Hao,Amy M. Holthaus,Amy M. Holthaus,Robert James,Anna Korkhin,Anna Korkhin,Larisa Litovchick,Larisa Litovchick,Jessica C. Mar,Theodore R. Pak,Sabrina Rabello,Renee Rubio,Yun Shen,Saurav Singh,Jennifer M. Spangle,Jennifer M. Spangle,Murat Tasan,Murat Tasan,Shelly Wanamaker,Shelly Wanamaker,James T. Webber,Jennifer Roecklein-Canfield,Jennifer Roecklein-Canfield,Eric Johannsen,Eric Johannsen,Albert-László Barabási,Rameen Beroukhim,Rameen Beroukhim,Rameen Beroukhim,Elliott Kieff,Elliott Kieff,Michael E. Cusick,David E. Hill,Karl Münger,Karl Münger,Jarrod A. Marto,John Quackenbush,Frederick P. Roth,James A. DeCaprio,James A. DeCaprio,Marc Vidal +71 more
TL;DR: It is shown that systematic analyses of host targets of viral proteins can identify cancer genes with a success rate on a par with their identification through functional genomics and large-scale cataloguing of tumour mutations, to increase the specificity of cancer gene identification.
Journal ArticleDOI
DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly
TL;DR: This work reports that DYRK1A can specifically phosphorylate LIN52 on serine residue 28, and that this phosphorylation is required for DREAM assembly, and reveals an important role for DYRk1A in the regulation of DREAM activity and entry into quiescence.
Journal ArticleDOI
A kinase shRNA screen links LATS2 and the pRB tumor suppressor.
Katrin Tschöp,Andrew R. Conery,Larisa Litovchick,James A. DeCaprio,Jeffrey Settleman,Ed Harlow,Nicholas J. Dyson +6 more
TL;DR: A functional connection between the pRB and Hippo tumor suppressor pathways is revealed, and it is suggested that low levels of LATS2 may undermine the ability of pRB to induce a permanent cell cycle arrest in tumor cells.
Journal ArticleDOI
Structural mechanisms of DREAM complex assembly and regulation.
Keelan Z. Guiley,Tyler J. Liban,Jessica Felthousen,Parameshwaran Ramanan,Larisa Litovchick,Seth M. Rubin +5 more
TL;DR: The structure explains the specificity for p107/p130 over Rb in the DREAM complex and how the complex is disrupted by viral oncoproteins and addressed how DREAM is disassembled upon cell cycle entry.