R
Ryan M. Walsh
Researcher at Harvard University
Publications - 25
Citations - 3665
Ryan M. Walsh is an academic researcher from Harvard University. The author has contributed to research in topics: Induced pluripotent stem cell & Cellular differentiation. The author has an hindex of 18, co-authored 22 publications receiving 3288 citations. Previous affiliations of Ryan M. Walsh include Howard Hughes Medical Institute.
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Journal ArticleDOI
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells
Jochen Utikal,Jose M. Polo,Matthias Stadtfeld,Nimet Maherali,Warakorn Kulalert,Ryan M. Walsh,Adam Khalil,James G. Rheinwald,Konrad Hochedlinger +8 more
TL;DR: The results show that the acquisition of immortality is a crucial and rate-limiting step towards the establishment of a pluripotent state in somatic cells and underscore the similarities between induced pluripotency and tumorigenesis.
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A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells
Jose M. Polo,Endre Anderssen,Endre Anderssen,Ryan M. Walsh,Benjamin A. Schwarz,Christian M. Nefzger,Sue Mei Lim,Marti Borkent,Marti Borkent,Effie Apostolou,Sara Alaei,Jennifer Cloutier,Ori Bar-Nur,Sihem Cheloufi,Matthias Stadtfeld,Maria E. Figueroa,Daisy A. Robinton,Sridaran Natesan,Ari Melnick,Jinfang Zhu,Sridhar Ramaswamy,Sridhar Ramaswamy,Konrad Hochedlinger,Konrad Hochedlinger +23 more
TL;DR: This integrative analysis allowed us to identify genes that act as roadblocks during reprogramming and surface markers that further enrich for cells prone to forming iPSCs, and offer new mechanistic insights into the nature and sequence of molecular events inherent to cellular reprograming.
Journal ArticleDOI
MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT.
Zhan Zhang,H. Sun,Hongyue Dai,Ryan M. Walsh,Maki Imakura,Janell M. Schelter,Julja Burchard,Xudong Dai,Aaron N. Chang,Robert L. Diaz,Joseph R. Marszalek,Steven R. Bartz,Michael Carleton,Michele A. Cleary,Peter S. Linsley,Carla Grandori +15 more
TL;DR: In this paper, the function of miR-210, the most prominent microRNA upregulated by hypoxia and a direct transcriptional target of HIFs, was investigated.
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Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells
Matthias Stadtfeld,Effie Apostolou,Francesco Ferrari,Jiho Choi,Ryan M. Walsh,Taiping Chen,Steen S.K. Ooi,Steen S.K. Ooi,Sang Yong Kim,Timothy H. Bestor,Toshi Shioda,Peter J. Park,Konrad Hochedlinger +12 more
TL;DR: It is shown that reprogramming in the presence of ascorbic acid attenuates hypermethylation of Dlk1-Dio3 by enabling a chromatin configuration that interferes with binding of the de novo DNA methyltransferase Dnmt3a.
Journal ArticleDOI
Functional genomics identifies therapeutic targets for MYC-driven cancer
Masafumi Toyoshima,Heather L. Howie,Maki Imakura,Ryan M. Walsh,James Annis,Aaron N. Chang,Jason Frazier,B. Nelson Chau,Andrey Loboda,Peter S. Linsley,Michele A. Cleary,Julie R. Park,Carla Grandori +12 more
TL;DR: Through a functional genomics approach, pathways essential in the context of oncogenic MYC but not to normal cells were identified, revealing a rich therapeutic space linked to a previously “undruggable” oncogene.