K
Kazu Nakazawa
Researcher at University of Alabama at Birmingham
Publications - 49
Citations - 6253
Kazu Nakazawa is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Hippocampal formation & Hippocampus. The author has an hindex of 29, co-authored 47 publications receiving 5618 citations. Previous affiliations of Kazu Nakazawa include National Institutes of Health & Massachusetts Institute of Technology.
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Journal ArticleDOI
Requirement for Hippocampal CA3 NMDA Receptors in Associative Memory Recall
Kazu Nakazawa,Michael C. Quirk,Raymond A. Chitwood,Masahiko Watanabe,Mark F. Yeckel,Linus D. Sun,Akira Kato,Akira Kato,Candice A. Carr,Candice A. Carr,Daniel Johnston,Matthew A. Wilson,Susumu Tonegawa,Susumu Tonegawa +13 more
TL;DR: Results provide direct evidence for CA3 NMDA receptor involvement in associative memory recall by generating and analyzing a genetically engineered mouse strain in which the N-methyl-d-asparate (NMDA) receptor gene is ablated specifically in the CA3 pyramidal cells of adult mice.
Journal ArticleDOI
Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes
Juan E. Belforte,Veronika Zsiros,Elyse R Sklar,Zhihong Jiang,Gu Yu,Yuqing Li,Elizabeth M. Quinlan,Kazu Nakazawa +7 more
TL;DR: It is suggested that early postnatal inhibition of NMDAR activity in corticolimbic GABAergic interneurons contributes to the pathophysiology of schizophrenia-related disorders.
Journal ArticleDOI
NMDA receptors, place cells and hippocampal spatial memory.
Kazu Nakazawa,Thomas J. McHugh,Thomas J. McHugh,Matthew A. Wilson,Susumu Tonegawa,Susumu Tonegawa +5 more
TL;DR: The data that have emerged from in vivo hippocampal recording studies that indicate that the activity of hippocampal place cells during behaviour is an expression of a memory trace are discussed.
Journal ArticleDOI
NMDA receptor-dependent ocular dominance plasticity in adult visual cortex.
Nathaniel B. Sawtell,Mikhail Y. Frenkel,Benjamin D. Philpot,Kazu Nakazawa,Susumu Tonegawa,Mark F. Bear +5 more
TL;DR: In adult mice, depriving the dominant contralateral eye of vision leads to a persistent, NMDA receptor-dependent enhancement of the weak ipsilateral-eye inputs, providing in vivo evidence for metaplasticity as a mechanism for binocular competition and demonstrating that an ocular dominance shift can occur solely by the mechanisms of response enhancement.
Journal ArticleDOI
Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience.
Kazu Nakazawa,Linus D. Sun,Michael C. Quirk,Laure Rondi-Reig,Matthew A. Wilson,Susumu Tonegawa +5 more
TL;DR: It is shown that mice with NMDA receptor (NR) deletion restricted to CA3 pyramidal cells in adulthood are impaired in rapidly acquiring the memory of novel hidden platform locations in a delayed matching-to-place version of the Morris water maze task but are normal when tested with previously experienced platform locations.