M
Motoyuki Otsuka
Researcher at University of Tokyo
Publications - 158
Citations - 8126
Motoyuki Otsuka is an academic researcher from University of Tokyo. The author has contributed to research in topics: microRNA & Gene. The author has an hindex of 46, co-authored 148 publications receiving 7449 citations. Previous affiliations of Motoyuki Otsuka include National Presto Industries & Scripps Research Institute.
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Correction: Corrigendum: MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma
Kentaro Kojima,Akemi Takata,Charles Vadnais,Motoyuki Otsuka,Takeshi Yoshikawa,Masao Akanuma,Yuji Kondo,Young Jun Kang,Takahiro Kishikawa,Naoya Kato,Zhifang Xie,Weiping J. Zhang,Haruhiko Yoshida,Masao Omata,Alain Nepveu,Kazuhiko Koike +15 more
TL;DR: This Article contains errors in the numbering of several papers in the reference list; reference 34 is incorrectly listed as reference 44 and references 35 to 44 are incorrectly list as 34 to 43.
Journal ArticleDOI
Hypersusceptibility to Vesicular Stomatitis Virus Infection in Dicer1-Deficient Mice Is Due to Impaired miR24 and miR93 Expression
Motoyuki Otsuka,Qing Jing,Philippe Georgel,Liguo New,Jianming Chen,Johann Mols,Young Jun Kang,Zhengfan Jiang,Xin Du,Ryan Cook,Subash C. Das,Asit K. Pattnaik,Bruce Beutler,Jiahuai Han,Jiahuai Han +14 more
TL;DR: It is found that host miR24 and miR93 could target viral large protein (L protein) and phosphoprotein (P protein) genes, and a lack of miR 24 andMiR93 was responsible for increased VSV replication in Dicer1(d/d) cells, suggesting that hostmiRNA can play a role in host interactions with viruses.
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Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma
Vinod Kumar,Naoya Kato,Yuji Urabe,Atsushi Takahashi,Ryosuke Muroyama,Naoya Hosono,Motoyuki Otsuka,Ryosuke Tateishi,Masao Omata,Hidewaki Nakagawa,Kazuhiko Koike,Naoyuki Kamatani,Michiaki Kubo,Yusuke Nakamura,Koichi Matsuda +14 more
TL;DR: A previously unidentified locus in the 5′ flanking region of MICA on 6p21.33 was found to be strongly associated with HCV-induced HCC and the risk allele of rs2596542 was associated with lower soluble MICA protein levels in individuals withHCV- induced HCC.
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Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice
Motoyuki Otsuka,Min Zheng,Masaaki Hayashi,Jing-Dwan Lee,Osamu Yoshino,Sheng-Cai Lin,Jiahuai Han +6 more
TL;DR: The data indicate that the development and function of the ovarian CL is a physiological process that appears to be regulated by miRNAs and requires Dicer1 function.
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Serum metabolomics reveals γ-glutamyl dipeptides as biomarkers for discrimination among different forms of liver disease
Tomoyoshi Soga,Masahiro Sugimoto,Masashi Honma,Masayo Mori,Kaori Igarashi,Kasumi Kashikura,Satsuki Ikeda,Akiyoshi Hirayama,Takehito Yamamoto,Haruhiko Yoshida,Motoyuki Otsuka,Shoji Tsuji,Yutaka Yatomi,Tadayuki Sakuragawa,Hisayoshi Watanabe,Kouei Nihei,Takafumi Saito,Sumio Kawata,Hiroshi Suzuki,Masaru Tomita,Makoto Suematsu +20 more
TL;DR: In this paper, a metabolome profiling approach was applied to serum samples obtained from patients with different liver diseases, to discover noninvasive and reliable biomarkers for rapid-screening diagnosis of liver diseases.