K
Kazuki Nagata
Researcher at Tokyo University of Science
Publications - 12
Citations - 80
Kazuki Nagata is an academic researcher from Tokyo University of Science. The author has contributed to research in topics: Immune system & Tumor necrosis factor alpha. The author has an hindex of 2, co-authored 6 publications receiving 12 citations. Previous affiliations of Kazuki Nagata include Laboratory of Molecular Biology.
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Journal ArticleDOI
IL-10 in Mast Cell-Mediated Immune Responses: Anti-Inflammatory and Proinflammatory Roles.
Kazuki Nagata,Chiharu Nishiyama +1 more
TL;DR: In this paper, the role of interleukin (IL)-10, an anti-inflammatory cytokine, in MC-mediated immune responses, in which MCs play roles not only as initiators of the immune response but also as suppressors of excessive inflammation.
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Cooperative Regulation of the Mucosal Mast Cell-Specific Protease Genes Mcpt1 and Mcpt2 by GATA and Smad Transcription Factors.
Kazumi Kasakura,Kazumi Kasakura,Kazuki Nagata,Ryosuke Miura,Mayu Iida,Hikaru Nakaya,Hikaru Okada,Takahiro Arai,Yuko Kawakami,Toshiaki Kawakami,Takuya Yashiro,Chiharu Nishiyama +11 more
TL;DR: It is found that TGF-β induced mMCP-1 and -2 expression by accelerating the recruitment of GATA2 to the proximal regions of the Mcpt1 and Mcpt2 genes in mucosal MCs.
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Delta Opioid Receptor Agonists Ameliorate Colonic Inflammation by Modulating Immune Responses.
TL;DR: In this article, the effect of opioids on immune system by using selective agonists for δ opioid receptor was evaluated, and it was shown that KNT-127 inhibited the release of IL-6 and another inflammatory cytokine TNF-α from macrophages and accelerated the development of Tregs.
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Immunosuppressive effect of a non-proteinogenic amino acid from Streptomyces through inhibiting allogeneic T cell proliferation.
Takuya Yashiro,Fumiya Sakata,Takahiro Sekimoto,Tomohiro Shirai,Fumihito Hasebe,Kenichi Matsuda,Sumire Kurosawa,Shodai Suzuki,Kazuki Nagata,Kazumi Kasakura,Makoto Nishiyama,Chiharu Nishiyama +11 more
TL;DR: It is concluded that DADH suppresses DC-mediated T cell activation by targeting DCs, whereas ISP-1 targets T cells directly.
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The anti-inflammatory effect of the gut lactic acid bacteria-generated metabolite 10-oxo-cis-6,trans-11-octadecadienoic acid on monocytes.
Shuhei Hagiwara,Kazuki Nagata,Kazumi Kasakura,Fumiya Sakata,Shigenobu Kishino,Jun Ogawa,Takuya Yashiro,Chiharu Nishiyama +7 more
TL;DR: In this paper, the effect of polyunsaturated fatty acid metabolites on inflammatory cytokine expression in macrophages was evaluated and shown that 10-oxo-cis-6,trans-11-octadecadienoic acid (γKetoC) significantly suppressed LPS-induced IL-6 release from bone marrow-derived macrophage (BMMs), which was accompanied by reduced mRNA expression of IL6, TNF, and IL1b.