Showing papers in "Journal of Hepatology in 2002"

TL;DR: The frequency of cholangiocarcinoma is 13% and the risk of hepatobiliary carcinoma is constant after the first year after PSC diagnosis with an incidence rate of 1.5% per year, suggestive of an increased risk of pancreatic carcinoma in patients with PSC.

TL;DR: A hitherto unreported rise in age-standardized mortality rates from intrahepatic cholangiocarcinoma across four continents is presented.

TL;DR: Data indicate that this clone is derived from the genome of the NANBH agent and are consistent with the agent being similar to the togaviridae or flaviviridae, which should be of great value in the isolation and characterization of other unidentified infectious agents.

TL;DR: Oxidative cellular damage occurs frequently in livers with NAFLD and may be associated with some clinico-pathological features ofNAFLD including liver fibrosis and possibly, hepatocarcinogenesis.

TL;DR: It is established that leptin is an essential mediator of hepatic fibrosis in response to chronic liver injury, whether metabolic or toxic in aetiology.

TL;DR: The outcome of anti-HBe positive chronic hepatitis B is worsened by older age and persistent viral replication or hepatitis exacerbations in chronic hepatitis or in cirrhotic patients, respectively.

TL;DR: In patients with NASH cirrhosis, the development of treatable HCC is sufficiently common to warrant regular screening for this grave complication.

TL;DR: Corticosteroids improved short-term survival of patients with severe AH and age and serum creatinine are independent prognostic factors.

TL;DR: It is shown that steatosis in genotype 3 infected patients is a risk factor for progression of fibrosis, and patients with genotypes 3 and steatotic ought to be recommended for early therapeutic intervention.

TL;DR: MELD score is superior to Child-Pugh score as predictor of short-term outcome after TIPS, however, its accuracy decreases for long-term predictions and overrates death risk.

TL;DR: In this article, the development of major bile duct stenoses and the efficacy of endoscopic measures have been evaluated in a prospective study of 106 patients treated for up to 13 years with ursodeoxycholic acid.

TL;DR: In this study of inactive HBsAg carriers, the median serum HBV DNA level was 1300 copies/ml, the serum HBVsDNA level was below 10(5) copies/ ml in 98% of the patients, and remained stable; histological lesions were mild in all cases.

TL;DR: A heparin effect was only found in cirrhotic patients with infection, further confirming that infection significantly modifies coagulation in cirrhotics.

TL;DR: The interplay ofapoptosis in human liver diseases will be emphasized, and current-working models of apoptosis in liver injury will be bedelineated, highlighting areas ripe for future investiga-tion and clinical studies/trials.

TL;DR: Oxidant stress, as reflected in blood and urine by a wide range of pro- and antioxidant markers, is a significant feature of hepatitis C infection and may have a role in slowing disease progression to cirrhosis.

TL;DR: In severe AH, infliximab was well tolerated and associated with significant improvement in Maddrey's score at day 28, and these promising results should encourage larger trials assessing the effects of this therapy on survival.

TL;DR: Cognitive brain function was subclinically impaired in the cohort of HCV-infected patients as indicated by significantly prolonged P300 latencies and reduced P300 amplitudes, indicating a further extrahepatic manifestation of chronic hepatitis C.

TL;DR: Data show a significant and quick induction of CYP2E1 activity, already at moderate alcohol consumption, which may be of importance in the pathogenesis of alcoholic liver disease, of ethanol, drug and vitamin A interactions and in alcohol associated carcinogenesis.

TL;DR: The data suggest that HCV core protein may directly repress transcription of the HBV RNAs, which may contribute to suppression of HBV replication in patients coinfected with both viruses.

TL;DR: It is demonstrated for the first time that cell type-specific telomere shortening and senescence are linked to progression of human cirrhosis, implying that future therapies aiming to restore regenerative capacity during aging and chronic diseases will have to ensure efficient targeting of specific cell types within the affected organs.

TL;DR: Only a few patients with severe alcoholic cirrhosis undergo OLT, since most of them do not stop drinking and/or die soon, and those becoming abstinent often improve their liver function, which should be considered when improvement in liver function is lacking after 3 months of abstinence.

TL;DR: Most of the adverse events that occurred during the first 48 h of naltrexone therapy were consistent with opioid withdrawal-like phenomena and spontaneously disappeared 2 days after starting treatment.

TL;DR: This new drug might be useful in healing human disease and reduce hepatic fibrosis in rats experimentally induced by chronic administration of CCl(4) and bile-duct ligation.

TL;DR: TSA inhibits hepatoma cell growth in vitro, which is otherwise particularly resistant to chemotherapy, and its anti-proliferative activity is paralleled by a comparable rate of apoptosis.

TL;DR: Variations in responses to thioacetamide can be easily monitored by weekly weight changes to reduce mortality to zero and simultaneously increase the production and quality of cirrhosis induced in rats.

TL;DR: In this paper, the relationship between NF-kB activation and apoptosis has been investigated in hepatocytes and the expression and regulation of apoptosis-related genes were investigated in liver cells.

TL;DR: Recent and older evidence that is at odds with the current concepts about the role of HSC in fibrogenesis and the suitability of the in vitro model of socalled HSC ‘activation’ is compiled.