K
Kee Yew Wong
Researcher at Genome Institute of Singapore
Publications - 7
Citations - 3044
Kee Yew Wong is an academic researcher from Genome Institute of Singapore. The author has contributed to research in topics: Homeobox protein NANOG & SOX2. The author has an hindex of 7, co-authored 7 publications receiving 2915 citations. Previous affiliations of Kee Yew Wong include Agency for Science, Technology and Research.
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Journal ArticleDOI
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells.
Yuin-Han Loh,Qiang Wu,Joon Lin Chew,Joon Lin Chew,Vinsensius B. Vega,Weiwei Zhang,Weiwei Zhang,Xi Chen,Xi Chen,Guillaume Bourque,Joshy George,Bernard Leong,Jun Liu,Kee Yew Wong,Ken W. Sung,Charlie W.H. Lee,Xiao Dong Zhao,Kuo Ping Chiu,Leonard Lipovich,Vladimir A. Kuznetsov,Paul Robson,Paul Robson,Lawrence W. Stanton,Chia-Lin Wei,Yijun Ruan,Bing Lim,Bing Lim,Huck-Hui Ng,Huck-Hui Ng +28 more
TL;DR: By integrating RNA interference–mediated depletion of Oct4 and Nanog with microarray expression profiling, it is demonstrated that these factors can activate or suppress transcription, and it is shown that common core downstream targets are important to keep ES cells from differentiating.
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REST regulates distinct transcriptional networks in embryonic and neural stem cells.
Rory Johnson,Christina Hui‐Leng Teh,Galih Kunarso,Kee Yew Wong,Gopalan Srinivasan,Megan Cooper,Manuela Volta,Sarah Su-ling Chan,Sarah Su-ling Chan,Leonard Lipovich,Steven M. Pollard,R. Krishna Murthy Karuturi,Chia-Lin Wei,Noel J. Buckley,Lawrence W. Stanton,Lawrence W. Stanton +15 more
TL;DR: It is proposed that an extensive, pluripotency-specific recruitment profile lends REST a key role in the maintenance of the ESC phenotype.
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Generation of Multipotential Mesendodermal Progenitors from Mouse Embryonic Stem Cells via Sustained Wnt Pathway Activation
Manjiri Manohar Bakre,Aina Hoi,Jamie Chen Yee Mong,Yvonne Y. Koh,Kee Yew Wong,Lawrence W. Stanton,Lawrence W. Stanton +6 more
TL;DR: It is demonstrated here that sustained activation of the Wnt pathway activation can be utilized to generate lineage-specific progenitors from ESCs, which can be further differentiated into desired organ-specific cells.
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Activin and BMP4 synergistically promote formation of definitive endoderm in human embryonic stem cells.
Adrian Kee Keong Teo,Yusuf Ali,Kee Yew Wong,Hiram Chipperfield,Akila Sadasivam,Yogavalli Poobalan,Ee Kim Tan,Siew Tein Wang,Suman Abraham,Norihiro Tsuneyoshi,Lawrence W. Stanton,N. Ray Dunn +11 more
TL;DR: This synergism between Activin A and BMP4 during the in vitro differentiation of hESC into DE suggests a complex interplay between BMP and Activin/Nodal signalingDuring the in vivo allocation and expansion of the endoderm lineage.
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The Transcription Factor Zfp281 Controls Embryonic Stem Cell Pluripotency by Direct Activation and Repression of Target Genes
Zheng‐Xu Wang,Christina Hui‐Leng Teh,Caroline Man‐Yee Chan,Ci Chu,Michael Rossbach,Galih Kunarso,Tahira Bee Allapitchay,Kee Yew Wong,Lawrence W. Stanton,Lawrence W. Stanton +9 more
TL;DR: The identification of both activation and repression domains within Zfp281 suggests that this transcription factor plays bifunctional roles in regulating gene expression within the network.