V
Vladimir A. Kuznetsov
Researcher at State University of New York Upstate Medical University
Publications - 146
Citations - 11228
Vladimir A. Kuznetsov is an academic researcher from State University of New York Upstate Medical University. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 36, co-authored 134 publications receiving 10422 citations. Previous affiliations of Vladimir A. Kuznetsov include National Institutes of Health & National University of Singapore.
Papers
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Journal ArticleDOI
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells.
Yuin-Han Loh,Qiang Wu,Joon Lin Chew,Joon Lin Chew,Vinsensius B. Vega,Weiwei Zhang,Weiwei Zhang,Xi Chen,Xi Chen,Guillaume Bourque,Joshy George,Bernard Leong,Jun Liu,Kee Yew Wong,Ken W. Sung,Charlie W.H. Lee,Xiao Dong Zhao,Kuo Ping Chiu,Leonard Lipovich,Vladimir A. Kuznetsov,Paul Robson,Paul Robson,Lawrence W. Stanton,Chia-Lin Wei,Yijun Ruan,Bing Lim,Bing Lim,Huck-Hui Ng,Huck-Hui Ng +28 more
TL;DR: By integrating RNA interference–mediated depletion of Oct4 and Nanog with microarray expression profiling, it is demonstrated that these factors can activate or suppress transcription, and it is shown that common core downstream targets are important to keep ES cells from differentiating.
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A global map of p53 transcription-factor binding sites in the human genome.
Chia-Lin Wei,Qiang Wu,Vinsensius B. Vega,Kuo Ping Chiu,Patrick Ng,Tao Zhang,Atif Shahab,How Choong Yong,Yutao Fu,Zhiping Weng,Jianjun Liu,Xiao Dong Zhao,Joon-Lin Chew,Joon-Lin Chew,Yen Ling Lee,Vladimir A. Kuznetsov,Wing-Kin Sung,Lance D. Miller,Bing Lim,Bing Lim,Edison T. Liu,Qiang Yu,Huck-Hui Ng,Huck-Hui Ng,Yijun Ruan +24 more
TL;DR: A robust approach is described that couples chromatin immunoprecipitation (ChIP) with the paired-end ditag (PET) sequencing strategy for unbiased and precise global localization of transcription-factor binding sites (TFBS).
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Nonlinear dynamics of immunogenic tumors: Parameter estimation and global bifurcation analysis
TL;DR: The model exhibits a number of phenomena that are seen in vivo, including immunostimulation of tumor growth, "sneaking through" of the tumor, and formation of a tumor "dormant state".
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Genetic Reclassification of Histologic Grade Delineates New Clinical Subtypes of Breast Cancer
Anna V. Ivshina,Joshy George,Oleg Senko,Benjamin Mow,Thomas C. Putti,Johanna Smeds,Thomas Lindahl,Yudi Pawitan,Per Hall,Hans Nordgren,John Wong,Edison T. Liu,Jonas Bergh,Vladimir A. Kuznetsov,Lance D. Miller +14 more
TL;DR: The findings show that a genetic grade signature can improve prognosis and therapeutic planning for breast cancer patients, and support the view that low- and high-grade disease, as defined genetically, reflect independent pathobiological entities rather than a continuum of cancer progression.
Journal ArticleDOI
Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells.
Xiao Dong Zhao,Xu Han,Joon Lin Chew,Joon Lin Chew,Jun Liu,Kuo Ping Chiu,Andre Choo,Yuriy L. Orlov,Wing-Kin Sung,Wing-Kin Sung,Atif Shahab,Vladimir A. Kuznetsov,Guillaume Bourque,Steve Oh,Yijun Ruan,Huck-Hui Ng,Huck-Hui Ng,Chia-Lin Wei +17 more
TL;DR: These global histone methylation maps provide an epigenetic framework that enables the discovery of novel transcriptional networks and delineation of different genetic compartments of the pluripotent cell genome.