R
Raif S. Geha
Researcher at Boston Children's Hospital
Publications - 655
Citations - 46986
Raif S. Geha is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 112, co-authored 638 publications receiving 43559 citations. Previous affiliations of Raif S. Geha include Harvard University & Saga Group.
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Journal ArticleDOI
Primary Immunodeficiency Diseases: An Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency
Waleed Al-Herz,Aziz Bousfiha,Jean-Laurent Casanova,Jean-Laurent Casanova,Helen Chapel,Mary Ellen Conley,Mary Ellen Conley,Charlotte Cunningham-Rundles,Amos Etzioni,Alain Fischer,José Luis Franco,Raif S. Geha,Lennart Hammarström,Shigeaki Nonoyama,Luigi D. Notarangelo,Luigi D. Notarangelo,Hans D. Ochs,Jennifer M. Puck,Chaim M. Roifman,Reinhard Seger,Mimi L.K. Tang,Mimi L.K. Tang +21 more
TL;DR: The updated classification of primary immunodeficiencies (PIDs) compiled by the Expert Committee of the International Union of Immunological Societies acts as a current reference of the knowledge of these conditions and is an important aid for the molecular diagnosis of patients with these rare diseases.
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The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM
Joan Sayós,Chengbin Wu,Massimo Morra,Ninghai Wang,X. Zhang,D. Allen,S. van Schaik,Luigi D. Notarangelo,Raif S. Geha,Maria Grazia Roncarolo,Hans C. Oettgen,J. E. De Vries,Gregorio Aversa,Cox Terhorst +13 more
TL;DR: It is shown that a T-cell-specific, SLAM-associated protein (SAP), which contains an SH2 domain and a short tail, acts as an inhibitor by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region.
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TACI is mutant in common variable immunodeficiency and IgA deficiency.
Emanuela Castigli,Stephen A. Wilson,Lilit Garibyan,Rima Rachid,Francisco A. Bonilla,Lynda C. Schneider,Raif S. Geha +6 more
TL;DR: It is suggested that TACI mutations can result in CVID and IgAD, the same condition as common variable immunodeficiency and IgA deficiency.
Journal ArticleDOI
Primary immunodeficiency diseases: An update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee
Raif S. Geha,Luigi D. Notarangelo,Jean-Laurent Casanova,Helen Chapel,Mary Ellen Conley,Alain Fischer,Lennart Hammarström,Shigeaki Nonoyama,Hans D. Ochs,Jennifer M. Puck,Chaim M. Roifman,Reinhard Seger,Josiah Wedgwood +12 more
TL;DR: In its last meeting in Jackson Hole, Wyo, after 3 days of intense scientific presentations and discussions, the committee has updated the classification of PID, as reported in this article.
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Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice.
Jonathan M. Spergel,Emiko Mizoguchi,Joanne P. Brewer,Thomas R. Martin,Atul K. Bhan,Raif S. Geha +5 more
TL;DR: A murine model of epicutaneous (EC) sensitization to the protein allergen, chicken egg albumin, ovalbumin, OVA results in a rise in total and OVA-specific serum IgE and leads to the development of a dermatitis characterized by infiltration of CD3(+) T cells, eosinophils, and neutrophils.