K
Keisuke Tachibana
Researcher at Osaka University
Publications - 55
Citations - 1911
Keisuke Tachibana is an academic researcher from Osaka University. The author has contributed to research in topics: Peroxisome proliferator-activated receptor & Medicine. The author has an hindex of 15, co-authored 47 publications receiving 1677 citations.
Papers
More filters
Journal ArticleDOI
Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome
Toshiya Tanaka,Joji Yamamoto,Satoshi Iwasaki,Hiroshi Asaba,Hiroki Hamura,Yukio Ikeda,Mitsuhiro Watanabe,Kenta Magoori,Ryoichi X. Ioka,Keisuke Tachibana,Yuichiro Watanabe,Yasutoshi Uchiyama,Koichi Sumi,Haruhisa Iguchi,Sadayoshi Ito,Takefumi Doi,Takao Hamakubo,Makoto Naito,Johan Auwerx,Masashi Yanagisawa,Tatsuhiko Kodama,Juro Sakai +21 more
TL;DR: Analysis of rat L6 myotubes treated with the PPARδ subtype-selective agonist, GW501516, by the Affymetrix oligonucleotide microarrays revealed that PPAR Δ is pivotal to control the program for fatty acid oxidation in the skeletal muscle, thereby ameliorating obesity and insulin resistance through its activation in obese animals.
Journal ArticleDOI
The Role of PPARs in Cancer.
TL;DR: The function of PPARs in tumor growth is reviewed and it is shown that these receptors are molecular targets for the development of drugs treating metabolic syndrome and cancer cell growth.
Journal ArticleDOI
Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms
Keisuke Tachibana,Yumi Kobayashi,Toshiya Tanaka,Masayuki Tagami,Akira Sugiyama,Tatsuya Katayama,Chihiro Ueda,Daisuke Yamasaki,Kenji Ishimoto,Mikako Sumitomo,Yasutoshi Uchiyama,Takahide Kohro,Juro Sakai,Takao Hamakubo,Tatsuhiko Kodama,Takefumi Doi +15 more
TL;DR: It was found that the expression of each PPAR subtype was tightly controlled by the concentration of doxycycline in these established cell lines and suggested that these cell lines are important tools used to identify the human PPARs-responsive genes.
Journal ArticleDOI
Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα-independent mechanisms.
Daisuke Yamasaki,Natsuko Kawabe,Hitomi Nakamura,Keisuke Tachibana,Kenji Ishimoto,Toshiya Tanaka,Hiroyuki Aburatani,Juro Sakai,Takao Hamakubo,Tatsuhiko Kodama,Takefumi Doi +10 more
TL;DR: The results suggest that fenofibrate suppresses Huh7 cell growth through a PPARα independent mechanism, and that CTMP is one of the key players for this antiproliferative property of fen ofibrate in Huh7 cells.
Journal ArticleDOI
Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells.
Kenji Ishimoto,Hiroki Nakamura,Keisuke Tachibana,Daisuke Yamasaki,Akemi Ota,Ken-ichi Hirano,Toshiya Tanaka,Takao Hamakubo,Juro Sakai,Tatsuhiko Kodama,Takefumi Doi +10 more
TL;DR: It is inferred that sterol-mediated regulation of lipin 1 gene transcription modulates triglyceride accumulation, which involves changes in the activity of phosphatidate phosphatase.