Showing papers in "European Journal of Cell Biology in 2011"

TL;DR: This review will cover the emerging roles of both ADAM10 and ADAM17 in the regulation of major physiological and developmental pathways and the suitability of specifically modulating the activities of both proteases as a feasible way to inhibit inflammatory states, cancer and neurodegeneration.

TL;DR: It is demonstrated that IL-6 trans-signaling is critically involved in generation and maintenance of several inflammatory and autoimmune diseases including chronic inflammatory bowel disease, rheumatoid arthritis, peritonitis and asthma, as well as inflammation-induced colon cancer.

TL;DR: This review aims to highlight recent discoveries with an emphasis on how vinculin is involved in the coordination of a network of signals.

TL;DR: Common principles and differences will be worked out at the levels of gene organization, enzymatic properties, cellular localization and regulation in chitin synthesis.

TL;DR: Recent data on immunomodulatory activities of Wnt proteins are reviewed and additional experiments using exogenous Wnt homologs further support the notion that TLR/NF-kappaB and Wnt signaling are functionally interconnected.

TL;DR: Future studies should establish the potential of IER3 as a new predictive marker and as a molecular target in human diseases such as cancer, inflammatory diseases or hypertension.

TL;DR: The present review not only summarizes the various modes of MKK4 and MKK7 activation and activity, but also extensively describes their impact on JNK signaling, their molecular interactions resulting in the formation of context-specific signalosomes and the functional consequences of JNK deficiency.

TL;DR: Human macrophage podosomes go 3D and take the shape of spherical podosome rosettes when the cells perform mesenchymal migration, which sets the scene for future studies of molecular and cellular processes regulating macrophages trans-migration.

TL;DR: The influences of the cellular context that regulate Notch activity are summarized and a model how the interplay between the cell-intrinsically established chromatin state and thecell-extrinsic signals that modify chromatin may select for Notch target accessibility and activation in different cellular contexts is proposed.

TL;DR: Clinification of the molecular mechanisms underlying UVR-induced immunosuppression will help to develop new immunosppressive therapeutic strategies by utilizing U VR-induced regulatory T cells for the treatment of immune-mediated diseases, and will contribute to a better understanding of photocarcinogenesis.

TL;DR: It is demonstrated that OPN directly stimulates angiogenesis via the avβ3/PI3-K/AKT/eNOS/NO signaling pathway and may play an important role in tumorigenesis by enhancing angiogenic in gliomas.

TL;DR: 3D analysis of invadosomes is now being actively developed in ex vivo and in vivo models to demonstrate their occurrence and establish their role in pathological and physiological processes.

TL;DR: Current knowledge about the structure, molecular composition and possible roles of the satellites that seem to surround the core of the centrosome in most animal cells are summarized.

TL;DR: The direct responsiveness of T lymphocytes to TLR ligands offers new perspectives for the immunotherapeutic manipulation of T cell responses.

TL;DR: HDAC6 is identified as a critical component of the invasive apparatus of tumor cells, in both two- and three-dimensional matrices, and the inhibition of HDAC6 by siRNA or treatment with HDAC inhibitor TSA results in a decreased invasion capacity.

TL;DR: Results suggest that tyrosine phosphorylation of VE-cadherin and claudin-5 is involved in the increased paracellular permeability of central nervous system-derived vascular endothelium induced by TGF-β1.

TL;DR: A proteomics approach is resorted to by applying DIfference Gel Electrophoresis (DIGE) to compare invadopodia-enriched sub-cellular fractions with cytosol and cell body membrane fractions and the whole cell lysate to reveal newly identified components ofInvadopoda and open further avenues to the molecular study of invasive growth behavior of cancer cells.

TL;DR: This review summarises the recent results on sensor structure and function, as well as the advances made regarding sensor mechanics.

TL;DR: The role of tricellulin in barrier properties, discriminating the involvement of the protein in paracellular permeability at bicellular and at tricellular tight junctions and the proposed molecular interactions with other tight junction proteins are addressed.

TL;DR: The results suggest that fenofibrate suppresses Huh7 cell growth through a PPARα independent mechanism, and that CTMP is one of the key players for this antiproliferative property of fen ofibrate in Huh7 cells.

TL;DR: Current knowledge on the mechanisms and regulation of endosome and vacuole membrane dynamics, and their role in organelle physiology are summarized.

TL;DR: The role of various factors in initiation and stability of podosomes and the roles of the Wiskott Aldrich Syndrome Protein (WASP) are discussed and recent data indicating that in a cellular context WASP is crucial not only for localised actin polymerisation at the leading edge and in Podosome cores but also for coordination of integrin clustering and activation during podosome formation and disassembly.

TL;DR: It is shown that PTRF/cavin-1-expressing PC3 cells exhibit decreased migration, and that this effect is mediated by reduced MMP9 production, and to a lesser extent, cavin-2, -3, and -4 all decreased MMP 9.

TL;DR: This review summarizes the work in the framework of the Collaborative Research Consortium 415 and provides facts and hypotheses about FasL-interacting proteins and their potential role in FasL biology.

TL;DR: It is proposed that the biosynthetic/secretory pathway might be critical for the polarized delivery of MT1-MMP to invadopodia that form as "default response" whenever cells have to deal with extracellular matrix of variable composition and stiffness.

TL;DR: It is demonstrated that irradiation causes RFP2 overexpression, which enhances ionizing radiation-induced apoptosis by increasing p53 stability and decreasing AKT kinase activity through MDM2 and AKT degradation.

TL;DR: It is suggested that distinct upstream activators are responsible for N-WASp/WASP activation in invadopodia and podosomes, and that all these ventral cell surface degradative structures have distinguishing molecular as well as structural characteristics.

TL;DR: The undulation and ruffling of theInvadopodial membrane together with the formation of dynamic filament-like extensions from the invadopODial cortactin core defines invadobodia as invasive superstructures that are distinct from the podosomes.

TL;DR: Results of the studies reviewed here help to understand the molecular basis of CXCL4's functional diversity and provide insights into integrated signaling processes in general.

TL;DR: Recent findings on a Glc-PTS-dependent metalloprotease, on the interaction of EIICB(Glc) with the regulatory peptide SgrT, and on the structure of the membrane spanning C-domain of the glucose transporter are reviewed and discussed and discussed in context of general PTS research.