K
Keith Hart
Researcher at Cardiff University
Publications - 14
Citations - 694
Keith Hart is an academic researcher from Cardiff University. The author has contributed to research in topics: Papillomaviridae & Epitope. The author has an hindex of 13, co-authored 14 publications receiving 661 citations. Previous affiliations of Keith Hart include University of Wales.
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Journal ArticleDOI
Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum.
Magdalena Plebanski,Katie L. Flanagan,Edwin A. M. Lee,William H. H. Reece,Keith Hart,Colin M. Gelder,Geraldine M. Gillespie,Margaret Pinder,Adrian V. S. Hill +8 more
TL;DR: It is shown that costimulation with naturally occurring altered peptide ligands (APL) can induce a rapid change from IFNgamma production to the immunosuppressive mediator interleukin 10 (IL-10).
Journal ArticleDOI
Associations between Human Leukocyte Antigens and Nonresponsiveness to Influenza Vaccine
Colin M. Gelder,Rob Lambkin,Keith Hart,Douglas M. Fleming,O. Martin Williams,Michael Bunce,Kenneth I. Welsh,Sara E. Marshall,John S. Oxford +8 more
TL;DR: Polymorphisms in HLA class II molecules appear to modulate antibody responses to influenza vaccination in at-risk groups where vaccination reduces complications of infection but is not universally protective.
Journal ArticleDOI
Novel Method for Detection, Typing, and Quantification of Human Papillomaviruses in Clinical Samples
Keith Hart,O. Martin Williams,Nicola Thelwell,Alison Nina Fiander,Tom Brown,Lesek K. Borysiewicz,Colin M. Gelder +6 more
TL;DR: A novel detection and typing methodology for human papillomaviruses (HPV) based on real-time PCR with the self-probing fluorescent primers known as Scorpions is reported, capable of estimating viral load per cell.
Journal ArticleDOI
Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation
Stephen Clark,Christopher P. Thomas,Victoria Jayne Hammond,Maceler Aldrovandi,Gavin William Grahame Wilkinson,Keith Hart,Robert C. Murphy,Peter William Collins,Valerie B. O'Donnell +8 more
TL;DR: In this article, a lipidomic method was used to identify Aminophospholipid (APL) trafficking across the plasma membrane is a key event in cell activation, apoptosis, and aging and is required for clearance of dying cells and coagulation.
Journal ArticleDOI
HLA Class II Polymorphisms and Susceptibility to Recurrent Respiratory Papillomatosis
Colin M. Gelder,O.M. Williams,Keith Hart,S. Wall,G. Williams,Duncan R. Ingrams,P. Bull,Michael Bunce,Kenneth I. Welsh,Sara E. Marshall,Leszek K. Borysiewicz +10 more
TL;DR: Recurrent respiratory papillomatosis (RRP) is characterised by multiple laryngeal papillomas, and since oral HPV infection is common and RRP is rare, other host and/or viral factors may contribute to pathogenesis.