Stephen Clark

TL;DR: It is proposed that platelet TLR4 is a threshold switch for this new bacterial trapping mechanism in severe sepsis, where NETs have the greatest capacity for bacterial trapping.

TL;DR: There was no significant between‐group difference in the rate of death from any cause at 10 years in the intention‐to‐treat analysis, and further studies are needed to determine whether multiple arterial grafts provide better outcomes than a single internal‐thoracic‐artery graft.

TL;DR: In this article, the authors investigated the incidence of invasive disease due to these pathogens during the early months of the COVID-19 pandemic and found that containment policies and public information campaigns likely reduced transmission of S pneumoniae, H influenzae, and N meningitidis, leading to a significant reduction in lifethreatening invasive diseases in many countries worldwide.

TL;DR: Nitration of lipids by NO- derived reactive species yields products with antiinflammatory properties, revealing a novel mechanism by which NO-derived nitrated biomolecules can influence the progression of vascular disease.

TL;DR: The results identify a TLR4 detection system within the blood-brain barrier and suggest the microglia play the role of sentinel cells detecting LPS thereby inducing endothelial activation and leading to efficient leukocyte recruitment to the CNS.