K
Kelley R. Healey
Researcher at William Paterson University
Publications - 24
Citations - 923
Kelley R. Healey is an academic researcher from William Paterson University. The author has contributed to research in topics: Candida glabrata & Echinocandin. The author has an hindex of 12, co-authored 21 publications receiving 695 citations. Previous affiliations of Kelley R. Healey include Rutgers Biomedical and Health Sciences & University of Medicine and Dentistry of New Jersey.
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Journal ArticleDOI
Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance.
Kelley R. Healey,Yanan Zhao,Winder B. Perez,Shawn R. Lockhart,Jack D. Sobel,Dimitrios Farmakiotis,Dimitrios Farmakiotis,Dimitrios P. Kontoyiannis,Dominique Sanglard,Saad J. Taj-Aldeen,Barbara D. Alexander,Cristina Jiménez-Ortigosa,Erika Shor,David S. Perlin +13 more
TL;DR: It is demonstrated that a mutator phenotype caused by a mismatch repair defect is prevalent in C. glabrata clinical isolates, and it is anticipated that identifying MSH2 defects in infecting strains may influence the management of patients on antifungal drug therapy.
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Limited ERG11 Mutations Identified in Isolates of Candida auris Directly Contribute to Reduced Azole Susceptibility.
Kelley R. Healey,Milena Kordalewska,Cristina Jiménez Ortigosa,Ashutosh Singh,Indira Berrio,Anuradha Chowdhary,David S. Perlin +6 more
TL;DR: Multiple Erg11 amino acid substitutions were identified in clinical isolates of Candida auris originating from India and Colombia; however, expression of alleles encoding I466M, Y501H, or other clade-defined amino acid differences yielded susceptible MICs.
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Fks1 and Fks2 Are Functionally Redundant but Differentially Regulated in Candida glabrata: Implications for Echinocandin Resistance
Santosh K. Katiyar,Ana Alastruey-Izquierdo,Kelley R. Healey,Michael E. Johnson,David S. Perlin,Thomas D. Edlind +5 more
TL;DR: RNA analysis suggests that transcriptional control is not the sole mechanism by which calcineurin modulates Fks2 activity, and attenuates the rate of resistance in Candida glabrata.
Journal ArticleDOI
Fungal Resistance to Echinocandins and the MDR Phenomenon in Candida glabrata.
Kelley R. Healey,David S. Perlin +1 more
TL;DR: The evolution of echinocandin resistance as a multistep model that includes general cell stress, drug adaptation (tolerance), and genetic escape is explored.
Journal ArticleDOI
Genetic Drivers of Multidrug Resistance in Candida glabrata
TL;DR: The mechanisms underlying the capacity of C. glabrata to rapidly develop resistance to multiple drug classes, including triazoles and echinocandins are discussed and a large number of distinct karyotypes within a single species are described.