W
Wenjia Qu
Researcher at Garvan Institute of Medical Research
Publications - 28
Citations - 1527
Wenjia Qu is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: DNA methylation & Prostate cancer. The author has an hindex of 17, co-authored 25 publications receiving 1265 citations. Previous affiliations of Wenjia Qu include Royal Prince Alfred Hospital.
Papers
More filters
Journal ArticleDOI
DNA Methylation: Bisulphite Modification and Analysis
TL;DR: This protocol for bisulphite conversion is the "gold standard" for DNA methylation analysis and facilitates identification and quantification ofDNA methylation at single nucleotide resolution.
Journal ArticleDOI
Methylome sequencing in triple-negative breast cancer reveals distinct methylation clusters with prognostic value.
Clare Stirzaker,Elena Zotenko,Jenny Z. Song,Wenjia Qu,Shalima S. Nair,Warwick J. Locke,Andrew Stone,Nicola J. Armstong,Mark D. Robinson,Alexander Dobrovic,Kelly A. Avery-Kiejda,Kate M. Peters,Juliet D. French,Sandra Stein,Darren Korbie,Matt Trau,John F. Forbes,Rodney J. Scott,Melissa A. Brown,Glenn Francis,Susan J. Clark +20 more
TL;DR: The data reveal that coordinated hypermethylation can occur in oestrogen receptor-negative disease, and that characterizing the epigenetic framework provides a potential signature to stratify TNBCs, demonstrating the feasibility of profiling the cancer methylome with limited archival tissue to identify regulatory regions associated with cancer.
Journal ArticleDOI
Conversion-specific detection of DNA methylation using real-time polymerase chain reaction (ConLight-MSP) to avoid false positives
TL;DR: It is recommended that MSP detection always should include a step to detect unconverted DNA to avoid overestimation of the frequency or level of methylated DNA in the sample.
Journal ArticleDOI
Impact of the genome on the epigenome is manifested in DNA methylation patterns of imprinted regions in monozygotic and dizygotic twins.
Marcel W. Coolen,Aaron L. Statham,Wenjia Qu,Megan Campbell,Anjali K. Henders,Grant W. Montgomery,Nicholas G. Martin,Susan J. Clark,Susan J. Clark +8 more
TL;DR: It is shown that for the first time, the rs10732516 [A] polymorphism, located in a critical CTCF binding site in the H19 ICR locus, is strongly associated with increased hypermethylation of specific CpG sites in the maternal H19 allele.
Journal ArticleDOI
Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer.
Joanna Achinger-Kawecka,Joanna Achinger-Kawecka,Fatima Valdes-Mora,Fatima Valdes-Mora,Phuc-Loi Luu,Phuc-Loi Luu,Katherine A. Giles,C. Elizabeth Caldon,Wenjia Qu,Shalima S. Nair,Sebastian Soto,Warwick J. Locke,Nicole S. Yeo-Teh,Cathryn M. Gould,Qian Du,Grady C. Smith,Irene Ramos,Kristine F Fernandez,Dave S.B. Hoon,Julia Margaret Wendy Gee,Clare Stirzaker,Clare Stirzaker,Susan J. Clark,Susan J. Clark +23 more
TL;DR: 3D epigenome remodelling at ER-bound enhancer-promoter interactions is a key mechanism underlying endocrine resistance in ER+ breast cancer.