K
Kelly J. Smith
Researcher at Johns Hopkins University
Publications - 9
Citations - 7038
Kelly J. Smith is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Familial adenomatous polyposis & Adenomatous polyposis coli. The author has an hindex of 9, co-authored 9 publications receiving 6911 citations. Previous affiliations of Kelly J. Smith include Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Identification of FAP locus genes from chromosome 5q21
Kenneth W. Kinzler,Mef Nilbert,Li Kuo Su,Bert Vogelstein,Tracy M. Bryan,Daniel B. Levy,Kelly J. Smith,Antonette C. Preisinger,Hedge Philip John,Douglas McKechnie,Rachel Finniear,Alex Markham,John Groffen,Mark S. Boguski,Stephen F. Altschul,Akira Horii,Hiroshi Ando,Yasuo Miyoshi,Yoshio Miki,Isamu Nishisho,Yusuke Nakamura +20 more
TL;DR: The APC gene was identified in a contig initiated from the MCC gene and was found to encode an unusually large protein, and these two closely spaced genes encode proteins predicted to contain coiled-coil regions, which were also expressed in a wide variety of tissues.
Journal ArticleDOI
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
Isamu Nishisho,Yusuke Nakamura,Yasuo Miyoshi,Yoshio Miki,Hiroshi Ando,Akira Horii,Kumiko Koyama,Joji Utsunomiya,Shozo Baba,Hedge Philip John,Alex Markham,Anne J. Krush,Gloria M. Petersen,Stanley R. Hamilton,Mef Nilbert,Daniel B. Levy,Tracy M. Bryan,Antonette C. Preisinger,Kelly J. Smith,Li Kuo Su,Kenneth W. Kinzler,Bert Vogelstein +21 more
TL;DR: The data suggest that more than one gene on chromosome 5q21 may contribute to colorectal neoplasia, and that mutations of the APC gene can cause both FAP and GS.
Journal ArticleDOI
Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.
Kenneth W. Kinzler,Mef Nilbert,Bert Vogelstein,Tracy M. Bryan,Daniel B. Levy,Kelly J. Smith,Antoneite C. Preisinger,Stanley R. Hamilton,Phil Hedge,Alex Markham,M. Carlson,Geoff Joslyn,Joanna Groden,Ray White,Yoshoi Miki,Yasuo Miyoshi,Isamu Nishisho,Yusuke Nakamura +17 more
TL;DR: A gene, MCC, which encodes an 829-amino acid protein with a short region of similarity to the G protein-coupled m3 muscarinic acetylcholine receptor is identified and is a candidate for the putative colorectal tumor suppressor gene located at chromosome region 5q21.
Journal Article
Molecular determinants of dysplasia in colorectal lesions.
Jin Jen,Steve M. Powell,Nickolas Papadopoulos,Kelly J. Smith,Stanley R. Hamilton,Bert Vogelstein,Kenneth W. Kinzler +6 more
TL;DR: Analysis of small benign colorectal lesions for APC and K-RAS mutations provides evidence that the nature and order of genetic changes can have a specific impact on both tumor morphology and the likelihood of tumor progression.
Journal ArticleDOI
The APC gene product in normal and tumor cells.
Kelly J. Smith,Karen A. Johnson,Tracy M. Bryan,David E. Hill,Sanford Markowitz,James K V Willson,Christos Paraskeva,Gloria M. Petersen,Stanley R. Hamilton,Bert Vogelstein,Kenneth W. Kinzler +10 more
TL;DR: These studies provide some initial clues to the function of the cytoplasmic protein APC and demonstrate the feasibility of identifying APC mutations by direct analysis of the APC protein.