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Anne J. Krush
Researcher at Johns Hopkins University
Publications - 74
Citations - 9814
Anne J. Krush is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Familial adenomatous polyposis & Cancer. The author has an hindex of 34, co-authored 74 publications receiving 9544 citations. Previous affiliations of Anne J. Krush include Johns Hopkins University School of Medicine & Utah State University.
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Journal ArticleDOI
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
Isamu Nishisho,Yusuke Nakamura,Yasuo Miyoshi,Yoshio Miki,Hiroshi Ando,Akira Horii,Kumiko Koyama,Joji Utsunomiya,Shozo Baba,Hedge Philip John,Alex Markham,Anne J. Krush,Gloria M. Petersen,Stanley R. Hamilton,Mef Nilbert,Daniel B. Levy,Tracy M. Bryan,Antonette C. Preisinger,Kelly J. Smith,Li Kuo Su,Kenneth W. Kinzler,Bert Vogelstein +21 more
TL;DR: The data suggest that more than one gene on chromosome 5q21 may contribute to colorectal neoplasia, and that mutations of the APC gene can cause both FAP and GS.
Journal ArticleDOI
Treatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis
Francis M. Giardiello,Stanley R. Hamilton,Anne J. Krush,Steven Piantadosi,Linda M. Hylind,Paul Celano,Susan V. Booker,C. Rahj Robinson,G. Johan A. Offerhaus +8 more
TL;DR: Sulindac reduces the number and size of colorectal adenomas in patients with familial adenomatous polyposis, but its effect is incomplete, and it is unlikely to replace colectomy as primary therapy.
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The Molecular Basis of Turcot's Syndrome
Stanley R. Hamilton,Bo Liu,Ramon Parsons,Nickolas Papadopoulos,Jin Jen,Steven M. Powell,Anne J. Krush,Theresa Berk,Zane Cohen,Bernard Têtu,Peter C. Burger,Patricia A. Wood,Fowzia Taqi,Susan V. Booker,Gloria M. Petersen,G. Johan A. Offerhaus,Anne C. Tersmette,Francis M. Giardiello,Bert Vogelstein,Kenneth W. Kinzler +19 more
TL;DR: The association between brain tumors and multiple colorectal adenomas can result from two distinct types of germ-line defects: mutation of the APC gene or mutation of a mismatch-repair gene.
Journal ArticleDOI
Increased Risk of Cancer in the Peutz–Jeghers Syndrome
Francis M. Giardiello,Steven B. Welsh,Stanley R. Hamilton,G. J. A. Offerhaus,A. M. Gittelsohn,Susan V. Booker,Anne J. Krush,John H. Yardley,Gordon D. Luk +8 more
TL;DR: It is suggested that patients with the Peutz-Jeghers syndrome have an increased risk for the development of cancer at gastrointestinal and nongastrointestinal sites.
Journal ArticleDOI
The risk of upper gastrointestinal cancer in familial adenomatous polyposis
G. Johan A. Offerhaus,Francis M. Giardiello,Anne J. Krush,Susan V. Booker,Anne C. Tersmette,N.Christopher Kelley,Stanley R. Hamilton +6 more
TL;DR: In this paper, the incidence rate of upper gastrointestinal cancer in patients with familial adenomatous polyposis in The Johns Hopkins Registry was compared with the rate of the general population through person-year analysis with adjustment for demographics.