M
Mef Nilbert
Researcher at Lund University
Publications - 235
Citations - 12876
Mef Nilbert is an academic researcher from Lund University. The author has contributed to research in topics: Cancer & Lynch syndrome. The author has an hindex of 47, co-authored 220 publications receiving 11835 citations. Previous affiliations of Mef Nilbert include Hvidovre Hospital & University of Copenhagen.
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Journal ArticleDOI
Identification of FAP locus genes from chromosome 5q21
Kenneth W. Kinzler,Mef Nilbert,Li Kuo Su,Bert Vogelstein,Tracy M. Bryan,Daniel B. Levy,Kelly J. Smith,Antonette C. Preisinger,Hedge Philip John,Douglas McKechnie,Rachel Finniear,Alex Markham,John Groffen,Mark S. Boguski,Stephen F. Altschul,Akira Horii,Hiroshi Ando,Yasuo Miyoshi,Yoshio Miki,Isamu Nishisho,Yusuke Nakamura +20 more
TL;DR: The APC gene was identified in a contig initiated from the MCC gene and was found to encode an unusually large protein, and these two closely spaced genes encode proteins predicted to contain coiled-coil regions, which were also expressed in a wide variety of tissues.
Journal ArticleDOI
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
Isamu Nishisho,Yusuke Nakamura,Yasuo Miyoshi,Yoshio Miki,Hiroshi Ando,Akira Horii,Kumiko Koyama,Joji Utsunomiya,Shozo Baba,Hedge Philip John,Alex Markham,Anne J. Krush,Gloria M. Petersen,Stanley R. Hamilton,Mef Nilbert,Daniel B. Levy,Tracy M. Bryan,Antonette C. Preisinger,Kelly J. Smith,Li Kuo Su,Kenneth W. Kinzler,Bert Vogelstein +21 more
TL;DR: The data suggest that more than one gene on chromosome 5q21 may contribute to colorectal neoplasia, and that mutations of the APC gene can cause both FAP and GS.
Journal ArticleDOI
Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.
Kenneth W. Kinzler,Mef Nilbert,Bert Vogelstein,Tracy M. Bryan,Daniel B. Levy,Kelly J. Smith,Antoneite C. Preisinger,Stanley R. Hamilton,Phil Hedge,Alex Markham,M. Carlson,Geoff Joslyn,Joanna Groden,Ray White,Yoshoi Miki,Yasuo Miyoshi,Isamu Nishisho,Yusuke Nakamura +17 more
TL;DR: A gene, MCC, which encodes an 829-amino acid protein with a short region of similarity to the G protein-coupled m3 muscarinic acetylcholine receptor is identified and is a candidate for the putative colorectal tumor suppressor gene located at chromosome region 5q21.
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The predictive value of KRAS, NRAS, BRAF, PIK3CA and PTEN for anti-EGFR treatment in metastatic colorectal cancer: A systematic review and meta-analysis
TL;DR: Meta-analysis suggests that mutations in KRAS exons 3 and 4, NRAS, BRAF and PIK3CA and non-functional PTEN predict resistance to anti-EGFR therapies and demonstrates that biomarker analysis beyond KRas exon 2 should be implemented for prediction of clinical benefit from anti- EGFR antibodies in metastatic colorectal cancer.
Journal ArticleDOI
Uterine leiomyoma cytogenetics.
Mef Nilbert,Sverre Heim +1 more
TL;DR: Karyotypic similarities exist also between leiomyoma and pleomorphic adenoma of the salivary gland, which includes a subset of tumors with anomalies of 12q13‐15, and with myxoid liposarcoma, which has t(12;16)(q13;p11) as a tumor‐specific rearrangement.