L
Lonny R. Levin
Researcher at Cornell University
Publications - 124
Citations - 10380
Lonny R. Levin is an academic researcher from Cornell University. The author has contributed to research in topics: Soluble adenylyl cyclase & Adenylyl cyclase. The author has an hindex of 49, co-authored 113 publications receiving 9453 citations. Previous affiliations of Lonny R. Levin include Cornell College & Cold Spring Harbor Laboratory.
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Journal ArticleDOI
Soluble Adenylyl Cyclase as an Evolutionarily Conserved Bicarbonate Sensor
Yanqiu Chen,Martin J. Cann,Tatiana N. Litvin,Vadim Iourgenko,Meeghan L. Sinclair,Lonny R. Levin,Jochen Buck +6 more
TL;DR: It is demonstrated here that bicarbonate directly stimulates mammalian soluble adenylyl cyclase (sAC) activity in vivo and in vitro in a pH-independent manner, which suggests that bICarbonate regulation of cAMP signaling plays a fundamental role in many biological systems.
Journal ArticleDOI
The Drosophila learning and memory gene rutabaga encodes a Ca2+/Calmodulin-responsive adenylyl cyclase.
Lonny R. Levin,Pyung Lim Han,Paul M. Hwang,Paul Feinstein,Ronald L. Davis,Ronald L. Davis,Randall R. Reed +6 more
TL;DR: Data confirm the identity of the rutabaga locus as the structural gene for the Ca2+/CaM-responsive adenylyl cyclase and show that the inactivation of this cyclase leads to a learning and memory defect.
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Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals
TL;DR: The two presumptive catalytic domains of sAC are closely related to cyanobacterial adenylyl cyclases, providing an evolutionary link between bacterial and mammalian signaling molecules.
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The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway
Daniel Broek,T. Toda,T. Michaeli,Lonny R. Levin,C. Birchmeier,Mark J. Zoller,Scott Powers,Michael Wigler +7 more
TL;DR: It is proposed that CDC25 regulates adenylate cyclase by regulating the guanine nucleotide bound to RAS proteins, suggesting that normal RAS is dependent on CDC25 function.
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Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation
Rebeca Acín-Pérez,Eric Salazar,Margarita Kamenetsky,Jochen Buck,Lonny R. Levin,Giovanni Manfredi +5 more
TL;DR: It is demonstrated for the first time the existence of a CO(2)-HCO(3)(-)-sAC-cAMP-PKA (mito-sAC) signaling cascade wholly contained within mitochondria, which serves as a metabolic sensor modulating ATP generation and ROS production in response to nutrient availability.