Ken-ichi Isobe

TL;DR: The proportion of elderly people rises in the developed countries and the increased susceptibility of the elderly to infectious diseases is caused by immune dysfunction, especially T cell functional decline, which is divided into two categories: an aging of immune cell itself and involvement of immune cells to age-related pathological changes.

TL;DR: It is found that transduction of 7EJ-Ras cells with a retroviral vector expressing GADD34 suppressed their proliferation, and that it suppresses cellular proliferation through the induction of cellular senescence.

TL;DR: In this article, the authors showed that the L1210-specific Lyt-2+ T cell clone, K7L, was insensitive to the antitumor activity of K7l and this property of tumor clones was stable after repeated in vitro passage, and definite tumor (L1210)-specific cytotoxic T lymphocyte (CTL) activity was developed by antigen restimulation in the culture of spleen cells from these mice.

TL;DR: The authors' aged iPSCs made teratomas when injected into the back skin of syngeneic mice, and differentiated to tissue cells of three germ lines in vitro, and showed strong alkaline phosphatase (AP) activity.

TL;DR: It is suggested that the oral mucosal tissue including MLN acts like Peyer's patches in GALT for IgA synthesis, which might in part explain the reason why MLN and ILN display distinct modes of response and sensitivity to the action of LPS.