K
Ken-ichi Isobe
Researcher at Nagoya University
Publications - 294
Citations - 18597
Ken-ichi Isobe is an academic researcher from Nagoya University. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 48, co-authored 293 publications receiving 16715 citations. Previous affiliations of Ken-ichi Isobe include Nagoya Women's University & Shubun University.
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GADD34 induces p53 phosphorylation and p21/WAF1 transcription.
Ayako Yagi,Yoshinori Hasegawa,Hengyi Xiao,Masataka Haneda,Eiji Kojima,Akihiko Nishikimi,Tadao Hasegawa,Kaoru Shimokata,Ken-ichi Isobe +8 more
TL;DR: Both GADD34 and p53 transfection induced much higher p21/WAF1 promoter activity, which was dependent on p53, and the promoter activity of p21 or WAF1 was very low in Gadd34 deficient MEF.
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Expression of MDR1 and glutatione S transferase-π genes and chemosensitivities in human gastrointestinal cancer
TL;DR: The relationship was analyzed between drug resistance and MDR1 (with MDR signifying multiple drug resistance) and glutatione S transferase‐π (GST‐π) gene expression in four stomach and four colon cancer cell lines, and high GST‐π mRNA expression was shown at the cellular level.
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Age‐dependent changes in projections from locus coeruleus to hippocampus dentate gyrus and frontal cortex
TL;DR: Results suggest that LC neurons give rise to axonal branching following the loss of projections to DG or FC with age, and suggest that a layer‐specific decline occurred with age in the noradrenergic axon terminals in DG.
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PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters.
TL;DR: Recombinant protein was shown to enhance the binding of BFCOL1 to its binding site in the mouse proalpha2(I) collagen proximal promoter in vitro, and it is speculated that PTRF might play a role in the RNA polymerase II reaction as well as that ofRNA polymerase I.
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Establishment of induced pluripotent stem cells from aged mice using bone marrow-derived myeloid cells
Zhao Cheng,Sachiko Ito,Naomi Nishio,Hengyi Xiao,Rong Zhang,Haruhiko Suzuki,Yayoi Okawa,Toyoaki Murohara,Ken-ichi Isobe +8 more
TL;DR: The efficiency of generating iPS cells from aged BM cultured in GM-CSF was low, but the differentiated BM-M-iPS cells proliferated well in the presence of GM- CSF, and lost expression of Nanog and Pou5f1, at least in part, due to methylation of their promoters.