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Ken-ichi Isobe

Researcher at Nagoya University

Publications -  294
Citations -  18597

Ken-ichi Isobe is an academic researcher from Nagoya University. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 48, co-authored 293 publications receiving 16715 citations. Previous affiliations of Ken-ichi Isobe include Nagoya Women's University & Shubun University.

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Journal Article

Oncogenicity of the ret transforming gene in MMTV/ret transgenic mice.

Takashi Iwamoto, +8 more
- 01 Apr 1990 - 
TL;DR: Transgenic mice that carry the ret oncogene driven by a mouse mammary tumor virus promoter/enhancer are successfully produced that develop mammary and salivary gland adenocarcinomas and high expression of the transgene was closely associated with the development of these tumors.
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Nitric oxide as an inflammatory mediator of radiation pneumonitis in rats.

Yasuhiro Nozaki, +6 more
- 01 Apr 1997 - 
TL;DR: In this paper, the authors investigated the mechanisms of radiation-induced pneumonitis using a model of unilaterally irradiated rats and showed that alveolar macrophages (AM) produced NO after irradiation, and the expression of inducible NO synthase (NOS) in both AM and epithelial cells was increased.
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Cancer incidence in old age.

Osamu Miyaishi, +4 more
- 15 Aug 2000 - 
TL;DR: The decrease in the metastatic ratio and less mortality due to cancer occurring at the oldest ages are considered due to the nature of cancer itself and the fact that the incidence of cancer does not increase would suggest that certain people among those of advanced age have a special resistance to it.
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Cinnabarinic acid generated from 3‐hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase

Rie Hiramatsu, +6 more
- 01 Jan 2008 - 
TL;DR: The CA generated from 3HAA possesses a strong apoptosis‐inducing activity in thymocytes through ROS generation, the loss of mitochondrial membrane potential, and caspase activation.
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Cooperative interaction of NF‐κB and C/EBP binding sites is necessary for manganese superoxide dismutase gene transcription mediated by lipopolysaccharide and interferon‐γ

Kayoko Maehara, +5 more
- 23 Apr 1999 - 
TL;DR: This report provides the first evidence that cooperation between two distinct cis‐acting elements may be required for induction of Mn‐SOD gene expression mediated by lipopolysaccharide and interferon‐γ.