K
Ken-ichi Isobe
Researcher at Nagoya University
Publications - 294
Citations - 18597
Ken-ichi Isobe is an academic researcher from Nagoya University. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 48, co-authored 293 publications receiving 16715 citations. Previous affiliations of Ken-ichi Isobe include Nagoya Women's University & Shubun University.
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Journal ArticleDOI
Simultaneous development of humoral and cellular tumor-specific immunity against L1210 mouse leukemia☆
Kohei Kawashima,Ken-ichi Isobe,Fumihiko Nagase,Takashi Yokochi,Eiichi Nagura,Yoshinori Hasegawa,Hiroshi Morishita,Kazumasa Yamada,Izumi Nakashima +8 more
TL;DR: Direct cytotoxic tests and competitive inhibition tests using tumor cells such as P388, LS-1 and L5178Y as target or inhibitor cells showed that the cell-mediated immunity is specific to L1210 leukemia.
Journal ArticleDOI
Genomic cloning and promoter analysis of the GAHSP40 gene
TL;DR: The new heat shock protein (GAHSP40), which binds to Gadd34, is a member of the Hsp40 family gene and has a J domain, which is similar to bacterial DNA
Journal Article
Cellular mechanism of primary anti-Thy-1 antibody responses in vitro induced by uniquely immunogenic thymocyte antigens.
Ken-ichi Isobe,I Nakashima,Fumihiko Nagase,Nobuo Kato,Kenji Mizoguchi,Kohei Kawashima,Phil Lake +6 more
TL;DR: Thy-1 or Thy-1-linked structures on thymocyte membranes have an intrinsic activity to directly signal either TI-2 B cells or immature T cells, or both, for activation in the presence of soluble factors released from adherent accessory cells.
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Novel hairless RET-transgenic mouse line with melanocytic nevi and anagen hair follicles.
Masashi Kato,Kozue Takeda,Yoshiyuki Kawamoto,Toyonori Tsuzuki,Yoko Kato,Tamio Ohno,Khaled Hossain,Imtiaz Iftakhar-E-Khuda,Nobutaka Ohgami,Ken-ichi Isobe,Masahide Takahashi,I Nakashima +11 more
Journal ArticleDOI
A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities
Kozue Takeda,Kozue Takeda,Yoshiyuki Kawamoto,Yoshiyuki Kawamoto,Yusuke Okuno,Masashi Kato,Masahide Takahashi,Haruhiko Suzuki,Ken-ichi Isobe,Izumi Nakashima,Izumi Nakashima +10 more
TL;DR: It is concluded that the M/IXXCW motif‐mediated mechanisms which initiate PTK activities are partially replaced by a PKC‐mediated mechanism.