M
Mitchell J. Cohen
Researcher at University of Colorado Denver
Publications - 280
Citations - 15675
Mitchell J. Cohen is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Coagulopathy & Resuscitation. The author has an hindex of 57, co-authored 263 publications receiving 12990 citations. Previous affiliations of Mitchell J. Cohen include Loyola University Medical Center & Clalit Health Services.
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Journal ArticleDOI
Transfusion of plasma, platelets, and red blood cells in a 1: 1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: The PROPPR randomized clinical trial
John B. Holcomb,Barbara C. Tilley,Sarah Baraniuk,Erin E. Fox,Charles E. Wade,Jeanette M. Podbielski,Deborah J. del Junco,Karen J. Brasel,Karen J. Brasel,Eileen M. Bulger,Rachael A. Callcut,Mitchell J. Cohen,Bryan A. Cotton,Timothy C. Fabian,Kenji Inaba,Jeffrey D. Kerby,Peter Muskat,Peter Muskat,Terence O'Keeffe,Sandro Rizoli,Bryce R.H. Robinson,Thomas M. Scalea,Martin A. Schreiber,Deborah M. Stein,Jordan A. Weinberg,Jeannie Callum,John R. Hess,Nena Matijevic,Christopher N. Miller,Jean-Francois Pittet,David B. Hoyt,Gail D. Pearson,Brian G. Leroux,Gerald van Belle +33 more
TL;DR: In this article, the effectiveness and safety of transfusing patients with severe trauma and major bleeding using plasma, platelets, and red blood cells in a 1:1:1 ratio compared with a 1 :1:2 ratio was evaluated.
Journal ArticleDOI
The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: Comparative effectiveness of a time-varying treatment with competing risks
John B. Holcomb,Deborah J. del Junco,Erin E. Fox,Charles E. Wade,Mitchell J. Cohen,Martin A. Schreiber,Louis H. Alarcon,Yu Bai,Karen J. Brasel,Eileen M. Bulger,Bryan A. Cotton,Nena Matijevic,Peter Muskat,John G. Myers,Herb A. Phelan,Christopher E. White,Jiajie Zhang,Mohammad H. Rahbar +17 more
TL;DR: Higher plasma and platelet ratios early in resuscitation were associated with decreased mortality in patients who received transfusions of at least 3 units of blood products during the first 24 hours after admission, and among survivors at 24 hours, the subsequent risk of death by day 30 was not associated with plasma or Platelet ratios.
Journal ArticleDOI
Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?
Karim Brohi,Mitchell J. Cohen,Michael T. Ganter,Michael A. Matthay,Robert C. Mackersie,Jean-Francois Pittet +5 more
TL;DR: Early traumatic coagulopathy occurs only in the presence of tissue hypoperfusion and appears to occur without significant consumption of coagulation factors, which is consistent with activated protein C activation and systemic anticoagulation.
Journal ArticleDOI
Acute Coagulopathy of Trauma: Hypoperfusion Induces Systemic Anticoagulation and Hyperfibrinolysis
Karim Brohi,Mitchell J. Cohen,Michael T. Ganter,Marcus J. Schultz,Marcel Levi,Robert C. Mackersie,Jean-Francois Pittet +6 more
TL;DR: Acute coagulopathy of trauma is associated with systemic hypoperfusion and is characterized by anticoagulation and hyperfibrinolysis, which correlates with thrombomodulin activity.
Journal ArticleDOI
Acute coagulopathy of trauma: mechanism, identification and effect.
TL;DR: The possible initiators, mechanism and clinical importance of acute coagulopathy of trauma are examined, with evidence to implicate activation of the protein C pathway in this process.