K
Kenji Kosaka
Researcher at Yokohama City University
Publications - 274
Citations - 20373
Kenji Kosaka is an academic researcher from Yokohama City University. The author has contributed to research in topics: Dementia with Lewy bodies & Dementia. The author has an hindex of 51, co-authored 274 publications receiving 18520 citations. Previous affiliations of Kenji Kosaka include Hochschule Hannover & Max Planck Society.
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Journal ArticleDOI
Wortmannin inhibits the activation of MAP kinase following vasopressin V1 receptor stimulation
Naoya Nishioka,Syu-ichi Hirai,Keiko Mizuno,Shin-ichi Osada,Atsushi Suzuki,Kenji Kosaka,Shigeo Ohno +6 more
TL;DR: The results suggest that wortmannin‐sensitive molecules such as PI3‐kinase, are involved in the V1 receptor‐mediated activation of the MAP kinase pathway independent of TPA‐sensitive PKC.
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SORL1 is Genetically Associated with Neuropathologically Characterized Late-Onset Alzheimer's Disease
Yanan Wen,Akinori Miyashita,Nobutaka Kitamura,Tamao Tsukie,Yuko Saito,Hiroyuki Hatsuta,Shigeo Murayama,Akiyoshi Kakita,Hitoshi Takahashi,Hiroyasu Akatsu,Takayuki Yamamoto,Kenji Kosaka,Haruyasu Yamaguchi,Kohei Akazawa,Yasuo Ihara,Ryozo Kuwano +15 more
TL;DR: This replication study strongly supports the preceding evidence that SORL1 is likely one of the genes associated with LOAD, and strong LD among SNPs was observed within each LD region, implying that there are two genomic regions showing association with LOad in SORl1.
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Ultrastructural and immunohistochemical study of degenerate neurite-bearing ghost tangles.
TL;DR: Some ghost tangles in the brains of Alzheimer patients were accompanied by many small argyrophilic structures which were electron microscopically confirmed to be degenerate neurites, and may have been induced by the amyloid nature of tubules, which probably provokes the reaction of neuropils.
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Cognitive conditions of pathologically confirmed dementia with Lewy bodies and Parkinson's disease with dementia
Yoshihiko Horimoto,Mitsuhiro Matsumoto,Hideka Nakazawa,Hiroyuki Yuasa,Manabu Morishita,Hiroyasu Akatsu,Hiroyuki Ikari,Takayuki Yamamoto,Kenji Kosaka +8 more
TL;DR: Dementia with Lewy bodies and Parkinson's disease with dementia were suspected to show cognitive impairment of similar severity in the terminal stage and would thus be difficult to classify as completely different entities.
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Cyclin-dependent kinase 5 (Cdk5) associated with Lewy bodies in diffuse Lewy body disease.
TL;DR: Investigation of the cyclin-dependent kinase (Cdk) 5 distribution pattern in diffuse Lewy body disease brains using immunohistochemistry suggests that Cdk5 may be associated with LB formation.