K
Kenji Kosaka
Researcher at Yokohama City University
Publications - 274
Citations - 20373
Kenji Kosaka is an academic researcher from Yokohama City University. The author has contributed to research in topics: Dementia with Lewy bodies & Dementia. The author has an hindex of 51, co-authored 274 publications receiving 18520 citations. Previous affiliations of Kenji Kosaka include Hochschule Hannover & Max Planck Society.
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Journal ArticleDOI
Developmental stages of cortical Lewy bodies and their relation to axonal transport blockage in brains of patients with dementia with Lewy bodies.
TL;DR: It is suggested that chronic axonal transport blockage is implicated in the development of cortical LB in DLB brains.
Journal ArticleDOI
Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies.
Akihiko Nunomura,Shigeru Chiba,Shigeru Chiba,Kenji Kosaka,Kenji Kosaka,Atsushi Takeda,Atsushi Takeda,Rudy J. Castellani,Rudy J. Castellani,Mark A. Smith,Mark A. Smith,George Perry,George Perry +12 more
TL;DR: Treatment with nuclease (DNase or RNase) before the immunostaining demonstrated that RNA was a major site of nucleic acid oxidation in brains of dementia with Lewy bodies, suggesting that neuronal RNA oxidation in dementia withLewy bodies might represent one of the fundamental abnormalities in age-associated neurodegenerative diseases.
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Alterations of muscarinic acetylcholine receptor subtypes in diffuse Lewy body disease: relation to Alzheimer’s disease
Kazumasa Shiozaki,Eizo Iseki,Haruaki Uchiyama,Yasuhiro Watanabe,Tatsuya Haga,Kimihiko Kameyama,Tomoaki Ikeda,Takayuki Yamamoto,Kenji Kosaka +8 more
TL;DR: The higher proportions of m1 in DLBD and m2 in Alzheimer’s disease suggest that the manner of degeneration in the cholinergic system is different between the diseases.
Journal ArticleDOI
Somatostatin and vasoactive intestinal polypeptide in postmortem brains from patients with Alzheimer-type dementia
TL;DR: Results suggest that involvement of not only somotostatin- but also VIP-containing neurons may not be ruled out in ATD brains.
Journal ArticleDOI
Corticobasal degeneration with primary progressive aphasia and accentuated cortical lesion in superior temporal gyrus: case report and review
Kenji Ikeda,Haruhiko Akiyama,Shuji Iritani,Koichi Kase,Tetsuaki Arai,Kazuhiro Niizato,Noriomi Kuroki,Kenji Kosaka +7 more
TL;DR: A survey of 28 pathologically evaluated cases of CBD revealed two similar cases, both of which began with progressive aphasia and presented cortical degeneration in the superior temporal gyrus, which are thought to represent a type of CBD.