K
Kenji Maeda
Researcher at Nagoya University
Publications - 263
Citations - 8512
Kenji Maeda is an academic researcher from Nagoya University. The author has contributed to research in topics: Medicine & Glycation. The author has an hindex of 46, co-authored 221 publications receiving 7566 citations. Previous affiliations of Kenji Maeda include Kitasato University & Tokai University.
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Journal ArticleDOI
The Cloning of PIG-A, a Component in the Early Step of GPI-Anchor Biosynthesis
Toshio Miyata,Junji Takeda,Yoshiyasu Iida,Norio Yamada,Norimitsu Inoue,Minoru Takahashi,Kenji Maeda,Teruo Kitani,Taroh Kinoshita +8 more
TL;DR: The glycosylphosphatidylinositol (GPI) anchor is a membrane attachment structure of many proteins and occurs in a wide variety of eukaryotes from yeasts to mammals and the structure of the core of the GPI anchor is conserved in protozoa and mammals.
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β2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis-associated amyloidosis
Toshio Miyata,Osamu Oda,Reiko Inagi,Yoshiyasu Iida,Norie Araki,Norio Yamada,Seikoh Horiuchi,Naoyuki Taniguchi,Kenji Maeda,Taroh Kinoshita +9 more
TL;DR: Evidence is provided that AGE-modified beta 2M is a dominant constituent of the amyloid deposits in hemodialysis-associated amyloidsosis.
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Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy.
Katsunori Horie,Toshio Miyata,Kenji Maeda,S Miyata,Satoshi Sugiyama,Hideto Sakai,C van Ypersole de Strihou,Vincent M. Monnier,Joseph L. Witztum,Kiyoshi Kurokawa +9 more
TL;DR: It is suggested that the colocalization of markers of glycoxidation (pentosidine and CML) with a marker of lipid peroxidation reflects a local oxidative stress in association with the pathogenesis of diabetic glomerular lesions in DN.
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Implication of an increased oxidative stress in the formation of advanced glycation end products in patients with end-stage renal failure
Toshio Miyata,Yoshinao Wada,Zhe Cai,Yoshiyasu Iida,Katsunori Horie,Yoshinari Yasuda,Kenji Maeda,Kiyoshi Kurokawa,Charles van Ypersele de Strihou +8 more
TL;DR: It is shown that, in uremia, CML and pentosidine production is determined both by an increased oxidative stress and the availability of precursors such as oxiAA, which suggests that AGE, that is, C ML andpentosidine, production is accelerated under oxidative stress, even in the absence of glucose.
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Mass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy.
Yoshiyuki Hiki,Hiroko Odani,Mami Takahashi,Yoshinari Yasuda,Akeyo Nishimoto,Hitoo Iwase,Toru Shinzato,Yutaka Kobayashi,Kenji Maeda +8 more
TL;DR: The results indicate that the decreased sialylation and galactosylation of the IgA1 hinge glycopeptides play a crucial role in its glomerular deposition in IgAN.