K
Kenji Shimizu
Researcher at Kyoto University
Publications - 3
Citations - 442
Kenji Shimizu is an academic researcher from Kyoto University. The author has contributed to research in topics: Receptor tyrosine kinase & Vascular endothelial growth factor C. The author has an hindex of 3, co-authored 3 publications receiving 428 citations. Previous affiliations of Kenji Shimizu include Ehime University & University of Helsinki.
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Journal ArticleDOI
Involvement of vascular endothelial growth factor receptor-3 in maintenance of integrity of endothelial cell lining during tumor angiogenesis.
Hajime Kubo,Takashi Fujiwara,Takashi Fujiwara,Takashi Fujiwara,Lotta Jussila,Lotta Jussila,Lotta Jussila,Hiroyuki Hashi,Hiroyuki Hashi,Hiroyuki Hashi,Minetaro Ogawa,Minetaro Ogawa,Minetaro Ogawa,Kenji Shimizu,Kenji Shimizu,Kenji Shimizu,Masaaki Awane,Masaaki Awane,Masaaki Awane,Yoshiharu Sakai,Yoshiharu Sakai,Yoshiharu Sakai,Arimichi Takabayashi,Arimichi Takabayashi,Arimichi Takabayashi,Kari Alitalo,Kari Alitalo,Kari Alitalo,Yoshio Yamaoka,Yoshio Yamaoka,Yoshio Yamaoka,Shin-Ichi Nishikawa,Shin-Ichi Nishikawa,Shin-Ichi Nishikawa +33 more
TL;DR: It is demonstrated that the inactivation of VEGFR-3 by a novel blocking monoclonal antibody (mAb) suppresses tumor growth by inhibiting the neo-angiogenesis of tumor-bearing tissues and suggests that the VEGF-C/VEG FR-3 pathway may serve another candidate target for cancer therapy.
Journal ArticleDOI
Suppression of VEGFR-3 signaling inhibits lymph node metastasis in gastric cancer.
Kenji Shimizu,Hajime Kubo,Koji Yamaguchi,Kazuhiko Kawashima,Yoshihide Ueda,Koichi Matsuo,Masaaki Awane,Yasuyuki Shimahara,Arimichi Takabayashi,Yoshio Yamaoka,Seiji Satoh +10 more
TL;DR: Antilymphangiogenesis by inhibiting VEGFR‐3 signaling could provide a potential strategy for the prevention of lymph node metastasis in gastric cancer.
Journal ArticleDOI
Increased expression of cytosolic chaperonin CCT in human hepatocellular and colonic carcinoma.
Shin-ichi Yokota,Yuzo Yamamoto,Kenji Shimizu,Hirohito Momoi,Tatsuhiko Kamikawa,Yoshio Yamaoka,Hideki Yanagi,Takashi Yura,Hiroshi Kubota +8 more
TL;DR: The results suggest that CCT is up-regulated in rapidly proliferating tumor cells in vivo to effectively produce proteins required for growth, and may serve as a useful tumor marker because it is widely distributed in the cytosol.