T
Takashi Fujiwara
Researcher at Bunka Gakuen University
Publications - 3
Citations - 631
Takashi Fujiwara is an academic researcher from Bunka Gakuen University. The author has contributed to research in topics: Receptor tyrosine kinase & Vascular endothelial growth factor C. The author has an hindex of 3, co-authored 3 publications receiving 591 citations. Previous affiliations of Takashi Fujiwara include Ehime University & University of Helsinki.
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Journal ArticleDOI
Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells
Akiyoshi Uemura,Minetaro Ogawa,Masanori Hirashima,Takashi Fujiwara,Shinji Koyama,Hitoshi Takagi,Yoshihito Honda,Stanley J. Wiegand,George D. Yancopoulos,Shin-Ichi Nishikawa +9 more
TL;DR: The potential of Ang1 as a new therapeutic modality for MC dropout in diseases such as diabetic retinopathies is demonstrated by showing that addition of recombinant modified angiopoietin-1 restored a hierarchical vasculature, and also rescued retinal edema and hemorrhage in the complete absence of MCs.
Journal ArticleDOI
Involvement of vascular endothelial growth factor receptor-3 in maintenance of integrity of endothelial cell lining during tumor angiogenesis.
Hajime Kubo,Takashi Fujiwara,Takashi Fujiwara,Takashi Fujiwara,Lotta Jussila,Lotta Jussila,Lotta Jussila,Hiroyuki Hashi,Hiroyuki Hashi,Hiroyuki Hashi,Minetaro Ogawa,Minetaro Ogawa,Minetaro Ogawa,Kenji Shimizu,Kenji Shimizu,Kenji Shimizu,Masaaki Awane,Masaaki Awane,Masaaki Awane,Yoshiharu Sakai,Yoshiharu Sakai,Yoshiharu Sakai,Arimichi Takabayashi,Arimichi Takabayashi,Arimichi Takabayashi,Kari Alitalo,Kari Alitalo,Kari Alitalo,Yoshio Yamaoka,Yoshio Yamaoka,Yoshio Yamaoka,Shin-Ichi Nishikawa,Shin-Ichi Nishikawa,Shin-Ichi Nishikawa +33 more
TL;DR: It is demonstrated that the inactivation of VEGFR-3 by a novel blocking monoclonal antibody (mAb) suppresses tumor growth by inhibiting the neo-angiogenesis of tumor-bearing tissues and suggests that the VEGF-C/VEG FR-3 pathway may serve another candidate target for cancer therapy.
Journal ArticleDOI
Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown
Shuntaro Ogura,Kaori Kurata,Yuki Hattori,Hiroshi Takase,Toshina Ishiguro-Oonuma,Yoonha Hwang,Soyeon Ahn,Inwon Park,Wataru Ikeda,Sentaro Kusuhara,Yoko Fukushima,Hiromi Nara,Hideto Sakai,Takashi Fujiwara,Jun Matsushita,Masatsugu Ema,Masanori Hirashima,Takashi Minami,Masabumi Shibuya,Nobuyuki Takakura,Pilhan Kim,Takaki Miyata,Yuichiro Ogura,Akiyoshi Uemura +23 more
TL;DR: The authors showed that transient inhibition of the pericytes recruitment to developing retinal vessels sustained EC-PC dissociations and BRB breakdown in adult mouse retinas, reproducing characteristic features of diabetic retinopathy such as hyperpermeability, hypoperfusion, and neoangiogenesis.